{"id":"W4318039932","doi":"10.26508/lsa.202201681","title":"SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β–induced synaptic pathology","year":2023,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Fonds de Recherche du Québec - Santé; Alzheimer Society Research Program; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec; McGill University; Institut de Recherche Clinique De Montréal; Canadian Institutes of Health Research; Alzheimer Society; Government of Canada","keywords":"Ectodomain; Synaptic vesicle; Neurexin; Neuroscience; Axon; Cell biology; Hippocampal formation; Biology; Presenilin; Chemistry; Alzheimer's disease; Receptor; Pathology; Vesicle; Biochemistry; Postsynaptic potential; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001275505,0.0005004668,0.0006187565,0.0002570253,0.0001765866,0.0002766525,0.0003541764,0.0003400219,0.001606495],"category_scores_gemma":[0.0001175051,0.0001496748,0.0003397198,0.0001443759,0.000281783,0.0001425361,0.0001492992,0.000938095,0.0005620224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002672998,"about_ca_system_score_gemma":0.0005243766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009947214,"about_ca_topic_score_gemma":0.00154095,"domain_scores_codex":[0.9998902,0.0000118866,0.00001290576,0.00001526692,0.00002956007,0.00004013864],"domain_scores_gemma":[0.9998906,0.000008992236,0.00002183117,0.000009157051,0.000012625,0.00005682314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001047586,0.0004886547,0.0002304052,0.0001248813,0.00003008349,0.0000913491,0.00001827953,0.0002538569,0.9939011,0.0001373194,0.0004207787,0.003255682],"study_design_scores_gemma":[0.0003013728,0.002532027,0.005474089,0.00001710798,0.00004540512,0.0003406447,0.00007756548,0.002162323,0.9851764,0.0001006457,0.003756543,0.000015779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996471,0.001169718,0.0005430769,0.0001452999,0.00006324478,0.00003017532,0.0005103952,0.0001274258,0.0009397597],"genre_scores_gemma":[0.9925252,0.001852196,0.0008739615,0.0000928014,0.00002054969,0.00005807679,0.001278616,0.00003107275,0.003267535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001606495,"threshold_uncertainty_score":0.005374253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06038624775807738,"score_gpt":0.355917843007447,"score_spread":0.2955315952493696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}