{"id":"W4318040054","doi":"10.1021/acsmedchemlett.2c00531","title":"Squaramide Tethered Clindamycin, Chloroquine, and Mortiamide Hybrids: Design, Synthesis, and Antimalarial Activity","year":2023,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Malaria Research and Control","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université Laval","keywords":"Plasmodium falciparum; Chloroquine; Clindamycin; IC50; Hydroxychloroquine; Chemistry; Malaria; In vitro; Pharmacology; Biology; Microbiology; Medicine; Biochemistry; Immunology; Antibiotics; Coronavirus disease 2019 (COVID-19); Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009516103,0.0002934313,0.0001580234,0.0001350341,0.000101437,0.0001768475,0.00024177,0.000287811,0.001435054],"category_scores_gemma":[0.0001332986,0.0001122478,0.0001618349,0.000150176,0.0001361069,0.0002508735,0.0001857307,0.0003507474,0.0003982656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002311939,"about_ca_system_score_gemma":0.0001319975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003110259,"about_ca_topic_score_gemma":0.000776768,"domain_scores_codex":[0.9999455,0.00001136183,0.000004566504,0.00001294948,0.00001230453,0.00001334152],"domain_scores_gemma":[0.9999623,0.000005677416,0.00001076558,0.000003650259,0.000006813841,0.00001085798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001287066,0.00004040764,0.0001587264,0.0002251057,0.00001934456,0.0002335663,0.00005073829,0.0007907393,0.9900399,0.0007962084,0.0001386002,0.007377875],"study_design_scores_gemma":[0.00005022141,0.002057038,0.001441018,0.00002269423,0.00003654062,0.0007003632,0.00005599505,0.001127465,0.9789611,0.0002008759,0.015318,0.00002877239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756199,0.00527328,0.009772814,0.0002226976,0.00005885409,0.0001726877,0.0006081145,0.0001211857,0.008150469],"genre_scores_gemma":[0.9874889,0.00225223,0.006996066,0.0001039684,0.00001164355,0.00007125323,0.000347933,0.00001350937,0.002714487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001435054,"threshold_uncertainty_score":0.004800677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02165517188055503,"score_gpt":0.2785457749274897,"score_spread":0.2568906030469347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}