{"id":"W4318040054","doi":"10.1021/acsmedchemlett.2c00531","title":"Squaramide Tethered Clindamycin, Chloroquine, and Mortiamide Hybrids: Design, Synthesis, and Antimalarial Activity","year":2023,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Malaria Research and Control","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université Laval","keywords":"Plasmodium falciparum; Chloroquine; Clindamycin; IC50; Hydroxychloroquine; Chemistry; Malaria; In vitro; Pharmacology; Biology; Microbiology; Medicine; Biochemistry; Immunology; Antibiotics; Coronavirus disease 2019 (COVID-19); Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009472005,0.0003011651,0.0005627648,0.00009645356,0.0001455227,0.00004880952,0.000145731,0.0001552969,0.0001277633],"category_scores_gemma":[0.001394752,0.0002565971,0.00007185986,0.0002642529,0.0004362771,0.0001118879,0.0001064173,0.0005850613,0.00002122781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000617227,"about_ca_system_score_gemma":0.0001438319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001262057,"about_ca_topic_score_gemma":0.000001797268,"domain_scores_codex":[0.997723,0.00009212976,0.0003031003,0.0005753255,0.0006484973,0.0006579545],"domain_scores_gemma":[0.9982105,0.000705767,0.0001057496,0.0003994686,0.00006844282,0.0005100774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001639153,0.0000531575,0.003911561,0.0004303325,0.0001852419,0.001117557,0.00007968127,0.00000570423,0.9774047,0.000005152044,0.00510514,0.01006265],"study_design_scores_gemma":[0.006654895,0.0002829137,0.1145934,0.0005047419,0.0005274011,0.0008901803,0.0003084958,0.002714319,0.871818,0.00008255244,0.001075004,0.0005480587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613095,0.0002644945,0.0006898767,0.03671246,0.00007721772,0.0004587698,0.00001402295,0.0001684406,0.0003052459],"genre_scores_gemma":[0.9969648,0.0003726945,0.0002024037,0.001330918,0.000731238,0.00008447156,0.0000215156,0.00004157118,0.0002503993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1106819,"threshold_uncertainty_score":0.9999886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02165517188055503,"score_gpt":0.2785457749274897,"score_spread":0.2568906030469347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}