{"id":"W4318045005","doi":"10.1186/s12967-023-03898-x","title":"A multi-omic analysis reveals the esophageal dysbiosis as the predominant trait of eosinophilic esophagitis","year":2023,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Eosinophilic Esophagitis","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Eosinophilic esophagitis; Computational biology; Microbiome; Dysbiosis; Transcriptome; Disease; Bioinformatics; Medicine; Biology; Pathology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002683472,0.0003142192,0.001217333,0.0009872507,0.0002034433,0.00001566728,0.0005465781,0.0001546615,0.001013002],"category_scores_gemma":[0.0009690532,0.0001601157,0.0008130434,0.002973055,0.000797127,0.0001515932,0.00003020266,0.0006631007,0.00002932575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006985189,"about_ca_system_score_gemma":0.0003225199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008492423,"about_ca_topic_score_gemma":0.00002666012,"domain_scores_codex":[0.9954215,0.0002886074,0.00183912,0.0002844963,0.001781932,0.0003843731],"domain_scores_gemma":[0.9958023,0.001712581,0.0009628916,0.0005330407,0.0007330556,0.0002560923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009372833,0.003669265,0.4252929,0.002072752,0.04953054,0.006864314,0.06719258,0.009856343,0.2712319,0.01030179,0.05466881,0.08994605],"study_design_scores_gemma":[0.007216022,0.001387482,0.9726656,0.0007612532,0.007549882,0.001708978,0.0005685441,0.00281566,0.001999993,0.002407646,0.0007441952,0.0001747611],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8285301,0.01178069,0.0007245884,0.1570669,0.0004878558,0.000839506,0.0001163358,0.00004159168,0.0004124613],"genre_scores_gemma":[0.9948695,0.0008049022,0.0009243086,0.001550364,0.0009863669,0.00001663152,0.00004756521,0.00004027354,0.0007600288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5473727,"threshold_uncertainty_score":0.9999002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03024713492299921,"score_gpt":0.320697153714594,"score_spread":0.2904500187915948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}