{"id":"W4318045038","doi":"10.3389/fimmu.2023.1070492","title":"Human antibodies targeting ENPP1 as candidate therapeutics for cancers","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Terry Fox Research Institute; University of British Columbia","funders":"National Institutes of Health; National Cancer Institute; Stand Up To Cancer; University of Pittsburgh","keywords":"Antibody; Cancer research; Cancer; Phage display; Adept; Cancer cell; Phosphodiesterase; Avidity; Ovarian cancer; Immunotherapy; Cancer immunotherapy; Chemistry; Medicine; Immunology; Enzyme; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003396061,0.0002394108,0.0004948556,0.0003948843,0.0003586175,0.0000116609,0.0003705362,0.0004707538,0.000131024],"category_scores_gemma":[0.00005718633,0.0002300858,0.0001148717,0.0003575516,0.000487397,0.00005406259,0.0001082175,0.0003801545,0.0001682659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002034141,"about_ca_system_score_gemma":0.0001575318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008483921,"about_ca_topic_score_gemma":0.0003181972,"domain_scores_codex":[0.9980764,0.0001840546,0.0003877929,0.0004487033,0.00002238819,0.0008806697],"domain_scores_gemma":[0.999429,0.00007579336,0.0001445971,0.000275087,0.00006220487,0.00001329938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006257014,0.000069325,0.07875042,0.00004882904,0.001321469,0.00002009293,0.00239797,0.00007062575,0.7196292,0.002906063,0.1698395,0.02432076],"study_design_scores_gemma":[0.004620578,0.0009986283,0.03118951,0.00004432735,0.00008665933,0.0000417132,0.005215889,0.0000419619,0.06095695,0.008072203,0.8880575,0.0006741237],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660345,0.02031623,0.0004944551,0.0007629456,0.009752835,0.0005627397,0.00008588991,0.0002689619,0.00172142],"genre_scores_gemma":[0.987241,0.002375382,0.0004566185,0.0005151207,0.00008785495,0.0002572747,0.0005355889,0.00004831747,0.008482818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.718218,"threshold_uncertainty_score":0.9382628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01425502887681392,"score_gpt":0.2791927828760288,"score_spread":0.2649377539992149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}