{"id":"W4318052559","doi":"10.3390/cancers15030737","title":"The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; McGill University; Lunenfeld-Tanenbaum Research Institute; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Fondation de l'Hôpital Général de Montréal; Cancer Research Society","keywords":"Kinase; Cancer research; Transcription factor; Cell biology; CRISPR; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460228,0.0003250522,0.000343738,0.0003854627,0.0001241209,0.0003182091,0.000248455,0.0002562274,0.001266151],"category_scores_gemma":[0.00007633463,0.0001279158,0.0002892847,0.0001394514,0.0002136898,0.0001476795,0.0002511389,0.000652637,0.0003473675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004521199,"about_ca_system_score_gemma":0.0003902212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000494055,"about_ca_topic_score_gemma":0.001139051,"domain_scores_codex":[0.9998314,0.00002603787,0.00001619107,0.00002550135,0.00005289039,0.00004787334],"domain_scores_gemma":[0.9999237,0.000008375539,0.00002061625,0.00001305747,0.000009240583,0.00002487891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001643919,0.00007507722,0.0002391268,0.00003852504,0.00001044446,0.00003359137,0.000006018376,0.0001287139,0.9961087,0.00009420511,0.00009216206,0.003009076],"study_design_scores_gemma":[0.00004039543,0.000348321,0.003187761,0.000004391173,0.0000212092,0.0001557343,0.00002321183,0.0009847607,0.9921581,0.00005903132,0.003012605,0.000004432431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920996,0.001932561,0.002117049,0.0001689732,0.00005106131,0.00005879738,0.0006195668,0.0003211406,0.002631221],"genre_scores_gemma":[0.9938864,0.0006638435,0.001302408,0.00008896903,0.000009438124,0.00003763663,0.0005104944,0.00003132362,0.003469444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001266151,"threshold_uncertainty_score":0.004235685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01830512068749757,"score_gpt":0.2651520996401197,"score_spread":0.2468469789526221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}