{"id":"W4318065812","doi":"10.3390/pharmaceutics15020410","title":"Safe and Effective Delivery of mRNA Using Modified PEI-Based Lipopolymers","year":2023,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"School of Medicine, Shanghai Jiao Tong University; National Natural Science Foundation of China; Shanghai Jiao Tong University; Natural Science Foundation of Shanghai","keywords":"Systemic administration; Gene delivery; Pharmacology; Transfection; Genetic enhancement; In vivo; Biocompatibility; Immune system; Messenger RNA; Nucleic acid; In vitro; Drug delivery; Chemistry; Biology; Immunology; Gene; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002685008,0.0003773751,0.0001802338,0.0001856975,0.00009353115,0.0002179482,0.0001756774,0.0002415085,0.00031513],"category_scores_gemma":[0.0002779401,0.0001098182,0.0001634225,0.0000937551,0.0002714324,0.0002718356,0.0001728784,0.0003577815,0.0002002724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000251137,"about_ca_system_score_gemma":0.0002849775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000222301,"about_ca_topic_score_gemma":0.0002715103,"domain_scores_codex":[0.9998171,0.00002586206,0.00001992412,0.00003998957,0.00007395086,0.00002330418],"domain_scores_gemma":[0.9998922,0.00002275225,0.0000510084,0.000007969885,0.00001832394,0.000007704018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002235375,0.000006512867,0.00004628431,0.0000465019,0.000002161507,0.00006726485,0.000009997007,0.0001130743,0.9968843,0.0002015564,0.00001932603,0.002580669],"study_design_scores_gemma":[0.00000420407,0.0000781579,0.0001289098,0.000002886818,0.000003966896,0.00009608746,0.000003399395,0.0004114,0.9982469,0.00002279795,0.0009990272,0.000002396029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8799606,0.005761718,0.1087231,0.0002645379,0.00009344128,0.0002402611,0.0001870094,0.0004597477,0.004309596],"genre_scores_gemma":[0.9468032,0.002902149,0.04610186,0.00009981329,0.00002938972,0.0001070951,0.0001935151,0.00005495836,0.003707988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003773751,"threshold_uncertainty_score":0.001822174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04458766688131691,"score_gpt":0.3361241895265136,"score_spread":0.2915365226451967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}