{"id":"W4318065960","doi":"10.21474/ijar01/15992","title":"EFFECT OFVARIATIONSIN ABCC2, CYP2C9, CYP2C19 & SCN2A GENESON TREATMENT RESPONSETO ANTICONVULSANTS- A SYSTEMATIC REVIEWAND META-ANALYSIS OF GENETIC ASSOCIATION STUDIES","year":2023,"lang":"en","type":"article","venue":"International Journal of Advanced Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Meta-analysis; CYP2C19; Publication bias; Medicine; Funnel plot; Internal medicine; Genetics; Biology; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0077111,0.0002121519,0.002090595,0.002346819,0.0001075395,0.00004003461,0.0003136754,0.00009200154,0.00009579235],"category_scores_gemma":[0.004422129,0.0001323903,0.001404134,0.001958002,0.00007518366,0.0001401467,0.00004328731,0.0002746221,0.0000349254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008765825,"about_ca_system_score_gemma":0.000258292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001617254,"about_ca_topic_score_gemma":0.00006951328,"domain_scores_codex":[0.9939358,0.001184034,0.001458194,0.000263951,0.002831116,0.0003268916],"domain_scores_gemma":[0.9908757,0.003606259,0.0009841776,0.0003500405,0.004051976,0.0001318726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.006935944,0.00123391,0.01931157,0.01037719,0.8186091,0.00199594,0.00521391,0.01292983,0.1162884,0.000375314,0.001102712,0.005626239],"study_design_scores_gemma":[0.0193655,0.009875407,0.1248021,0.01475594,0.7189047,0.0005316178,0.005666221,0.00231862,0.09272759,0.002378209,0.00750114,0.001172928],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643543,0.02952418,0.0007301237,0.003410304,0.0005730754,0.001213558,0.00009312974,0.00002564588,0.00007567745],"genre_scores_gemma":[0.9727858,0.01840652,0.003128909,0.00005392771,0.0001754097,0.0001120687,0.00005371521,0.00003351085,0.005250135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1054906,"threshold_uncertainty_score":0.5398719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2217455296232281,"score_gpt":0.5180893903447812,"score_spread":0.2963438607215531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}