{"id":"W4318065960","doi":"10.21474/ijar01/15992","title":"EFFECT OFVARIATIONSIN ABCC2, CYP2C9, CYP2C19 & SCN2A GENESON TREATMENT RESPONSETO ANTICONVULSANTS- A SYSTEMATIC REVIEWAND META-ANALYSIS OF GENETIC ASSOCIATION STUDIES","year":2023,"lang":"en","type":"article","venue":"International Journal of Advanced Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Meta-analysis; CYP2C19; Publication bias; Medicine; Funnel plot; Internal medicine; Genetics; Biology; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01378802,0.002639941,0.01588904,0.00664696,0.0005935616,0.003463232,0.001594857,0.00221726,0.002851338],"category_scores_gemma":[0.02610838,0.001189871,0.03095209,0.007832736,0.0006594497,0.001548763,0.00125994,0.001476154,0.0002066306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002113211,"about_ca_system_score_gemma":0.003810544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004752118,"about_ca_topic_score_gemma":0.01119202,"domain_scores_codex":[0.990375,0.004300694,0.002788251,0.0009910479,0.0012617,0.0002832417],"domain_scores_gemma":[0.9798406,0.01534319,0.003020003,0.0004818805,0.001143489,0.0001708331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001957464,0.00004459731,0.009252576,0.3284059,0.6389574,0.0001853563,0.00009422612,0.0005750835,0.000378039,0.0001571702,0.0005482004,0.019444],"study_design_scores_gemma":[0.0003293865,0.000186746,0.005137905,0.02491844,0.9673151,0.0001384769,0.00004451942,0.0001747713,0.00015622,0.0001660551,0.001412801,0.00001956078],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.004409853,0.9945363,0.0003201068,0.0001593918,0.00009976443,0.0001152888,0.0002159081,0.000009875963,0.00013354],"genre_scores_gemma":[0.1422126,0.8531387,0.00198466,0.000741865,0.0003080132,0.0006689484,0.0006380287,0.00002376222,0.0002832792],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01588904,"threshold_uncertainty_score":0.07291889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2217455296232281,"score_gpt":0.5180893903447812,"score_spread":0.2963438607215531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}