{"id":"W4318141890","doi":"10.1021/acsptsci.2c00219","title":"Signaling Modulation via Minimal C-Terminal Modifications of Apelin-13","year":2023,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec – Nature et technologies; Vrije Universiteit Brussel; Canada Foundation for Innovation; Université de Sherbrooke","keywords":"Apelin; Chemistry; Allosteric regulation; Agonist; Stereochemistry; EC50; Partial agonist; Ligand (biochemistry); Amide; Receptor; In vivo; Allosteric modulator; Potency; Endogeny; Biophysics; In vitro; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009835896,0.0002408678,0.0001616796,0.00005006264,0.00007921521,0.0001658669,0.0002175351,0.0002147118,0.001097739],"category_scores_gemma":[0.0001577986,0.00008162107,0.0001664278,0.00006710805,0.0001588649,0.000136968,0.0001567016,0.0004840373,0.0003030066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001637864,"about_ca_system_score_gemma":0.0001311068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000321672,"about_ca_topic_score_gemma":0.0004226668,"domain_scores_codex":[0.9999353,0.00001517708,0.000006217575,0.00001160852,0.00001287603,0.00001885388],"domain_scores_gemma":[0.9999162,0.00001530502,0.00003050211,0.000009115619,0.000009949292,0.00001894208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002396222,0.00002503138,0.00005533666,0.00002120323,0.000004654349,0.00005863625,0.000008562568,0.000183863,0.9985777,0.0000603443,0.00001706163,0.0007480009],"study_design_scores_gemma":[0.0000476016,0.0009553904,0.0009467073,0.000004081589,0.00001369722,0.0002184649,0.0000142251,0.000679011,0.9955004,0.00003000546,0.001583749,0.000006726682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982493,0.000204147,0.0008021638,0.00002896326,0.000009134281,0.00001430892,0.00007004349,0.00001527137,0.0006067342],"genre_scores_gemma":[0.9971909,0.0003030182,0.001354807,0.00006215451,0.000006572219,0.00001708959,0.0001738281,0.000007864237,0.0008838016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001097739,"threshold_uncertainty_score":0.003672302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06014075050379537,"score_gpt":0.4064220857199513,"score_spread":0.3462813352161559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}