{"id":"W4318141890","doi":"10.1021/acsptsci.2c00219","title":"Signaling Modulation via Minimal C-Terminal Modifications of Apelin-13","year":2023,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec – Nature et technologies; Vrije Universiteit Brussel; Canada Foundation for Innovation; Université de Sherbrooke","keywords":"Apelin; Chemistry; Allosteric regulation; Agonist; Stereochemistry; EC50; Partial agonist; Ligand (biochemistry); Amide; Receptor; In vivo; Allosteric modulator; Potency; Endogeny; Biophysics; In vitro; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001238885,0.0001160795,0.0001913391,0.0005685815,0.0002636559,0.000009827051,0.0003141316,0.0001203565,0.0006047608],"category_scores_gemma":[0.0001391776,0.0001061477,0.00007297677,0.00250395,0.001398653,0.0002310132,0.00004499763,0.0003089276,0.0002164888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000610236,"about_ca_system_score_gemma":0.0008325579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001890175,"about_ca_topic_score_gemma":0.000001527448,"domain_scores_codex":[0.9974392,0.00005662662,0.0004497179,0.0004065651,0.001204906,0.0004429695],"domain_scores_gemma":[0.9985874,0.0004411938,0.00009504017,0.0001400328,0.000464501,0.0002718162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001387083,0.0001262654,0.002283092,0.00002759627,0.00002862378,0.00001868704,0.0002789761,0.001731408,0.9820076,0.0002658192,0.0002566984,0.01283653],"study_design_scores_gemma":[0.001859136,0.0002171154,0.4340014,0.0000384188,0.0001366197,0.00005070219,0.00005672334,0.4547435,0.1067517,0.001398166,0.0005782034,0.0001683493],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985809,0.00005696966,0.005823566,0.007049359,0.0002104446,0.0004094115,0.00002054334,0.00008312092,0.0005375982],"genre_scores_gemma":[0.997609,0.00003335864,0.001590881,0.0002585871,0.0001683626,0.00003258504,0.00007336809,0.00001124647,0.0002226722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8752559,"threshold_uncertainty_score":0.6621707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06014075050379537,"score_gpt":0.4064220857199513,"score_spread":0.3462813352161559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}