{"id":"W4318166203","doi":"10.1002/anie.202214935","title":"Supramolecular Polyphenol‐DNA Microparticles for In Vivo Adjuvant and Antigen Co‐Delivery and Immune Stimulation","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; University of Melbourne; Medical Research Council; RMIT University; Institute of Infection and Immunity; China Scholarship Council; Australian National Fabrication Facility","keywords":"DNA; Adjuvant; DNA vaccination; Supramolecular chemistry; Antigen; Ovalbumin; Chemistry; Nucleic acid; Guanine; Gene delivery; Molecular biology; Tannic acid; In vivo; Immune system; Plasmid; Biology; Biochemistry; Gene; Genetic enhancement; Nucleotide; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001328697,0.0001067543,0.00009765493,0.00009278393,0.00004735702,0.00003933114,0.00007711564,0.00008947255,0.00002267877],"category_scores_gemma":[0.00005969725,0.0001135802,0.00004058506,0.00005856038,0.00005536597,0.00002177808,0.00005946018,0.00004064057,0.000005105548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001605666,"about_ca_system_score_gemma":0.00001901998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004149875,"about_ca_topic_score_gemma":0.00002462456,"domain_scores_codex":[0.9992905,0.00001185733,0.0001826341,0.0002659951,0.00009976451,0.0001492852],"domain_scores_gemma":[0.9996976,0.00002332903,0.00005513612,0.00009126955,0.00009518868,0.00003753727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001368907,0.00002414617,0.003905697,0.00001358515,0.0000342498,0.000003845303,0.00007400264,0.0000290409,0.9914975,0.00003189324,0.003320329,0.0009288325],"study_design_scores_gemma":[0.0007649171,0.0001092586,0.01913287,0.00003296132,0.000008443038,0.000008715208,0.0001289111,0.000557675,0.9748714,0.0003410075,0.003914031,0.0001298046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977157,0.000476932,0.0007000103,0.0003604835,0.000220393,0.0001576891,0.0001440584,0.00001595147,0.0002087888],"genre_scores_gemma":[0.9972562,0.0008853764,0.0001229518,0.0001657207,0.0003272062,0.00004242172,0.0009866424,0.00001361833,0.0001998337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01662609,"threshold_uncertainty_score":0.4631667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0137877157846707,"score_gpt":0.2703490215211884,"score_spread":0.2565613057365178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}