{"id":"W4318166203","doi":"10.1002/anie.202214935","title":"Supramolecular Polyphenol‐DNA Microparticles for In Vivo Adjuvant and Antigen Co‐Delivery and Immune Stimulation","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; University of Melbourne; Medical Research Council; RMIT University; Institute of Infection and Immunity; China Scholarship Council; Australian National Fabrication Facility","keywords":"DNA; Adjuvant; DNA vaccination; Supramolecular chemistry; Antigen; Ovalbumin; Chemistry; Nucleic acid; Guanine; Gene delivery; Molecular biology; Tannic acid; In vivo; Immune system; Plasmid; Biology; Biochemistry; Gene; Genetic enhancement; Nucleotide; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001281475,0.0001660429,0.0001396003,0.0001382903,0.00008418392,0.0001630278,0.0001228314,0.0002268326,0.0006293329],"category_scores_gemma":[0.00008953613,0.00009671976,0.0001242876,0.00009634116,0.0001326902,0.0001386244,0.0001547858,0.0002801543,0.0002442636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002041455,"about_ca_system_score_gemma":0.0001506191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001426148,"about_ca_topic_score_gemma":0.000304839,"domain_scores_codex":[0.9999571,0.000007475811,0.000002923945,0.00001112922,0.00001018647,0.00001116078],"domain_scores_gemma":[0.9999619,0.000009702923,0.000009759348,0.000003237358,0.000004432099,0.00001101009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002232677,0.00001502154,0.00003723655,0.00003116792,0.000003217992,0.0000228183,0.000006864198,0.0001052263,0.9971235,0.0001760997,0.00005032639,0.002406138],"study_design_scores_gemma":[0.00001073137,0.0001366238,0.0003175914,0.000002626104,0.000008477111,0.00007589415,0.000004077892,0.001531208,0.9957907,0.00005533799,0.002063347,0.000003521674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9438888,0.005648935,0.04705628,0.0002553535,0.0001185956,0.0001173974,0.0002197801,0.0004246067,0.002270155],"genre_scores_gemma":[0.9827318,0.001128423,0.01362912,0.00005873875,0.00001889933,0.00005276381,0.00009136126,0.0000240894,0.002264872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006293329,"threshold_uncertainty_score":0.002105355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0137877157846707,"score_gpt":0.2703490215211884,"score_spread":0.2565613057365178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}