{"id":"W4318166407","doi":"10.1111/andr.13399","title":"Transgenerational impact of grand‐paternal lifetime exposures to both folic acid deficiency and supplementation on genome‐wide DNA methylation in male germ cells","year":2023,"lang":"en","type":"article","venue":"Andrology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; Epigenetics; DNA methylation; Germ cell; Offspring; Sperm; Reprogramming; Methylation; Spermatogenesis; Somatic cell; Andrology; Germline; Genetics; Genomic imprinting; CpG site; Pregnancy; Endocrinology; Cell; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002670843,0.000106212,0.0001333777,0.0001788309,0.00004142406,0.00001003059,0.00006149169,0.00009082566,0.00005046234],"category_scores_gemma":[0.00002276314,0.0001005248,0.00005499026,0.0001402451,0.00002856206,0.000004983011,0.00002345584,0.00004051418,0.000006906033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001148764,"about_ca_system_score_gemma":0.00003963373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000664443,"about_ca_topic_score_gemma":0.0001770533,"domain_scores_codex":[0.9991294,0.00008837293,0.0002493275,0.0002471895,0.00009863322,0.0001870399],"domain_scores_gemma":[0.9997078,0.00002728306,0.00006581423,0.0001120333,0.00003377969,0.00005329227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001546094,0.00003552755,0.07514954,0.000007171194,0.00001522896,0.000001834947,0.0001910765,0.006665479,0.9166164,0.00002508339,0.00007038244,0.00106763],"study_design_scores_gemma":[0.0006663862,0.001388346,0.4130575,0.000002531487,0.000008285919,0.000001978944,0.000009631507,0.0001985866,0.5840836,0.0002423115,0.000247173,0.00009369149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974105,0.0002899419,0.001716898,0.0001201514,0.00006138725,0.0002018139,0.00006066487,0.000004756203,0.0001338582],"genre_scores_gemma":[0.9986728,0.0004043879,0.0002540302,0.00008399119,0.00006593271,0.00002381649,0.0004063227,0.00001117145,0.00007756057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.337908,"threshold_uncertainty_score":0.4099284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332747729308548,"score_gpt":0.2904458229530297,"score_spread":0.2771183456599443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}