{"id":"W4318166407","doi":"10.1111/andr.13399","title":"Transgenerational impact of grand‐paternal lifetime exposures to both folic acid deficiency and supplementation on genome‐wide DNA methylation in male germ cells","year":2023,"lang":"en","type":"article","venue":"Andrology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; Epigenetics; DNA methylation; Germ cell; Offspring; Sperm; Reprogramming; Methylation; Spermatogenesis; Somatic cell; Andrology; Germline; Genetics; Genomic imprinting; CpG site; Pregnancy; Endocrinology; Cell; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002611948,0.0003773948,0.0003275269,0.0004968191,0.0001920414,0.0003763147,0.0003654714,0.0004914311,0.003022861],"category_scores_gemma":[0.0001937798,0.0002396665,0.0002964428,0.000163094,0.0005213991,0.0002553424,0.0003161845,0.0009768412,0.0003224703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000418556,"about_ca_system_score_gemma":0.0004254978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001636898,"about_ca_topic_score_gemma":0.003174845,"domain_scores_codex":[0.9996125,0.00004666574,0.00002738961,0.000146146,0.0000889635,0.00007833524],"domain_scores_gemma":[0.9994085,0.00009016923,0.000160355,0.00007527515,0.00005352202,0.0002122493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006604904,0.00008334416,0.0008960803,0.00003144444,0.00001496149,0.00004477856,0.00004744,0.00003092189,0.996403,0.00007212374,0.00003858353,0.001676844],"study_design_scores_gemma":[0.00006026004,0.002875336,0.02608117,0.00001872523,0.0001142336,0.0002691093,0.0001690473,0.0005463772,0.9673433,0.00006464132,0.002441932,0.00001573831],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956527,0.0007900457,0.001526097,0.00008055653,0.00004382611,0.00003325709,0.000849903,0.00008328466,0.0009404008],"genre_scores_gemma":[0.9876871,0.000573663,0.002188047,0.00009700123,0.00001677188,0.0001089178,0.001119356,0.00007118235,0.008138053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003022861,"threshold_uncertainty_score":0.01011246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332747729308548,"score_gpt":0.2904458229530297,"score_spread":0.2771183456599443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}