{"id":"W4318168174","doi":"10.1128/aac.01331-22","title":"N-Phenylpyridine-3-Carboxamide and 6-Acetyl-1H-Indazole Inhibit the RNA Replication Step of the Dengue Virus Life Cycle","year":2023,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec; Université de Montréal; University of Saskatchewan; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Animal and Plant Health Agency; Mitacs; Québec Consortium for Drug Discovery; Innovation Saskatchewan; Government of Canada; Institut national de la recherche scientifique; Deutsche Forschungsgemeinschaft; University of Alberta; Armand-Frappier Foundation; Deutsches Zentrum für Infektionsforschung; Courtois Foundation; Aix-Marseille Université","keywords":"Dengue virus; Virology; Replicon; Biology; Dengue fever; Flavivirus; Viral replication; Antiviral drug; RNA; Subgenomic mRNA; Virus; DNA; Gene; Genetics; Plasmid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132849,0.0003505233,0.0003225709,0.0002351946,0.0001447812,0.0001233008,0.0004091528,0.0002381315,0.002071309],"category_scores_gemma":[0.0001326229,0.0001045627,0.0002613158,0.0001528061,0.000173469,0.0001321072,0.0001747865,0.0006955976,0.0006552135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000160119,"about_ca_system_score_gemma":0.0002205456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009177991,"about_ca_topic_score_gemma":0.002694883,"domain_scores_codex":[0.9999028,0.00001918135,0.000005799664,0.00001519418,0.00002347236,0.00003344639],"domain_scores_gemma":[0.9999522,0.000008134581,0.00001579683,0.000004167861,0.000006662206,0.00001292341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001465647,0.001026319,0.001089843,0.000987791,0.00007718478,0.000488002,0.00006921466,0.0006815121,0.8630589,0.001049674,0.003837789,0.1261681],"study_design_scores_gemma":[0.001928729,0.02127624,0.05736928,0.0002318939,0.0001538322,0.005402952,0.0001029656,0.004467426,0.816429,0.0003865103,0.09216387,0.00008729116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8284343,0.1326196,0.0080507,0.0009026864,0.0006652715,0.0004059284,0.0007399106,0.0007024939,0.02747907],"genre_scores_gemma":[0.9622338,0.02512582,0.00365376,0.0002100533,0.0001393953,0.0001783393,0.000562239,0.00002012547,0.007876524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002071309,"threshold_uncertainty_score":0.006929278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204673014822436,"score_gpt":0.2586269839984049,"score_spread":0.2465802538501805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}