{"id":"W4318192373","doi":"10.21203/rs.3.rs-2469338/v1","title":"Hierarchical structures of hematopoietic stem cells and their bone marrow niches are measured via immune privilege","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Columbia College","funders":"","keywords":"Stem cell; Biology; Immune system; Immune privilege; Cell biology; Bone marrow; Haematopoiesis; Niche; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001090553,0.0003968369,0.0006603094,0.0002230643,0.0001590308,0.00008097791,0.0005909734,0.0007648804,0.0000157681],"category_scores_gemma":[0.0001046002,0.000333205,0.0002968433,0.0001836744,0.0005227256,0.000003271085,0.001198401,0.001162946,0.000005200966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003690366,"about_ca_system_score_gemma":0.0002761841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001546098,"about_ca_topic_score_gemma":0.0001604897,"domain_scores_codex":[0.9967723,0.0005676745,0.0005269827,0.0008747405,0.0006432487,0.0006150551],"domain_scores_gemma":[0.9980021,0.0001382157,0.0001784334,0.001043227,0.0004242204,0.0002138743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002910298,0.0001230689,0.002870334,0.002802188,0.0001966959,0.00002230454,0.0004945073,0.00009073541,0.9898298,0.00005899432,0.0004490296,0.002771346],"study_design_scores_gemma":[0.0006533203,0.0003968463,0.008622322,0.0006890025,0.00002558249,0.0000173011,0.0005638623,0.0003022289,0.9832932,0.003789342,0.001188488,0.0004584506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860163,0.01074763,0.00105859,0.0003314895,0.0003413589,0.0008926259,0.0005140107,0.00004222709,0.00005582021],"genre_scores_gemma":[0.9966553,0.002030601,0.0002220249,0.00001272309,0.0002487765,0.00007723044,0.0002137147,0.0001001801,0.0004394554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01063905,"threshold_uncertainty_score":0.999912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05297745987556273,"score_gpt":0.3010746980453736,"score_spread":0.2480972381698108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}