{"id":"W4318197655","doi":"10.1039/d2nr03684c","title":"Complementary early-phase magnetic particle imaging and late-phase positron emission tomography reporter imaging of mesenchymal stem cells <i>in vivo</i>","year":2023,"lang":"en","type":"article","venue":"Nanoscale","topic":"Characterization and Applications of Magnetic Nanoparticles","field":"Engineering","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; Ontario Institute for Cancer Research; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Institute for Cancer Research","keywords":"Bioluminescence imaging; Mesenchymal stem cell; Positron emission tomography; Molecular imaging; Sodium-iodide symporter; Stem cell; Reporter gene; Magnetic particle imaging; In vivo; Magnetic resonance imaging; Preclinical imaging; Medicine; Nuclear medicine; Biomedical engineering; Materials science; Pathology; Chemistry; Cell culture; Transfection; Radiology; Biology; Nanotechnology; Magnetic nanoparticles; Gene expression; Cell biology; Nanoparticle; Luciferase; Symporter; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001519855,0.0001324022,0.0001688192,0.0001396056,0.00005166969,0.00003862461,0.00009070808,0.00002303978,0.000119944],"category_scores_gemma":[0.000002375947,0.0001409929,0.0000414533,0.0004728452,0.00005580764,0.000143721,0.00005521659,0.00006138284,0.000008823846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001394561,"about_ca_system_score_gemma":0.000006389639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000025597,"about_ca_topic_score_gemma":0.000004151318,"domain_scores_codex":[0.998904,0.00002498001,0.0004275294,0.000215204,0.0001544457,0.0002738706],"domain_scores_gemma":[0.999549,0.00003948814,0.00005345726,0.0002255171,0.00002579172,0.0001067349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001885723,0.0001128304,0.03574041,0.00004570825,0.000003934862,0.00001956903,0.000292541,0.00006938638,0.9460762,0.00001125924,0.0009744427,0.01663494],"study_design_scores_gemma":[0.002257799,0.00006548613,0.01495219,0.00005263488,0.0000228004,0.000006683661,0.0001990135,0.08300328,0.8970193,0.00006394353,0.002169555,0.000187272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984818,0.0002968593,0.0001682337,0.0002949766,0.00008783323,0.0002599648,0.00006233001,0.0001876163,0.0001604365],"genre_scores_gemma":[0.9994568,0.00005573519,0.0001928557,0.00004458526,0.0000182469,0.000029438,0.00001661275,0.00002458435,0.0001611261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0829339,"threshold_uncertainty_score":0.5749522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008210256021121635,"score_gpt":0.2408869049742677,"score_spread":0.2326766489531461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}