{"id":"W4318197735","doi":"10.1002/ange.202214935","title":"Supramolecular Polyphenol‐DNA Microparticles for In Vivo Adjuvant and Antigen Co‐Delivery and Immune Stimulation","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; University of Melbourne; Medical Research Council; RMIT University; Institute of Infection and Immunity; China Scholarship Council; Australian National Fabrication Facility","keywords":"Supramolecular chemistry; DNA; Chemistry; Adjuvant; DNA vaccination; Guanine; Gene delivery; Antigen; DNA origami; Nucleic acid; Ovalbumin; DNA nanotechnology; Molecular biology; Biophysics; Nanotechnology; Biochemistry; Plasmid; Biology; Gene; Transfection; Materials science; Nucleotide; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264693,0.0001574975,0.000110883,0.00012777,0.00008581715,0.0001563578,0.0001161041,0.0002051181,0.0006451799],"category_scores_gemma":[0.00008893893,0.00008530989,0.0001067386,0.00007231486,0.0001288455,0.0001091632,0.0001330621,0.0002353437,0.0002157988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002033546,"about_ca_system_score_gemma":0.0001333002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001491559,"about_ca_topic_score_gemma":0.000280362,"domain_scores_codex":[0.9999621,0.000006583486,0.000002595027,0.00000965316,0.000008345434,0.00001068527],"domain_scores_gemma":[0.9999509,0.000011629,0.00001236814,0.000004353628,0.000005569596,0.00001509056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002070001,0.00001762244,0.00003712749,0.00001934488,0.000002477631,0.00001983439,0.000005817529,0.0001138914,0.9984097,0.0001308703,0.0000384294,0.001184038],"study_design_scores_gemma":[0.00001281323,0.0001208631,0.0002736617,0.000001661485,0.00000547708,0.0000439575,0.00000302695,0.00162292,0.996825,0.00003328383,0.001054792,0.000002549752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787133,0.001320173,0.0182745,0.0001309564,0.00005670972,0.0000597754,0.0001178187,0.0002096085,0.001117182],"genre_scores_gemma":[0.9924326,0.0002478398,0.005986409,0.00002906135,0.000008653478,0.000027749,0.00004153115,0.00001266131,0.001213446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006451799,"threshold_uncertainty_score":0.002158403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564358310520882,"score_gpt":0.2625595752847779,"score_spread":0.246915992179569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}