{"id":"W4318217624","doi":"10.1016/j.celrep.2023.112046","title":"Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NHLBI Division of Intramural Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Horizon 2020; Fudan University; European Research Council; University of Illinois at Urbana-Champaign; National Institutes of Health; College of Natural Resources and Sciences, Humboldt State University; Ministry of Science and Higher Education of the Russian Federation; Alexander von Humboldt-Stiftung; Institut Gustave-Roussy; Université de Montréal; Centre National de la Recherche Scientifique; Ministry of Education and Science of the Russian Federation; Institut National Du Cancer; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Institut National de la Santé et de la Recherche Médicale; Massachusetts General Hospital; Technische Universität Dresden; Fondation ARC pour la Recherche sur le Cancer; National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; European Commission; National Psoriasis Foundation; Horizon 2020 Framework Programme; Etablissement Français du Sang; Aix-Marseille Université","keywords":"Biology; Computational biology; Mononuclear phagocyte system; Myeloid; Metabolic network; Phagocyte; Identification (biology); Immune system; Cell biology; Immunology; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005029088,0.0007022504,0.0005682405,0.001727253,0.0005965857,0.0005718272,0.0006167144,0.0005278738,0.001522882],"category_scores_gemma":[0.001260419,0.0001550882,0.001041633,0.002019878,0.0003165633,0.0003789449,0.000719568,0.0006227354,0.0005925578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006535346,"about_ca_system_score_gemma":0.0005389209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006175231,"about_ca_topic_score_gemma":0.01221022,"domain_scores_codex":[0.9996014,0.00008699259,0.00001983525,0.0001763524,0.00006085364,0.00005457211],"domain_scores_gemma":[0.9995031,0.000205573,0.00008647073,0.00007152792,0.00008423637,0.00004897693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004077771,0.0006956212,0.3205004,0.005812449,0.002356563,0.001325692,0.001006252,0.1309519,0.3231376,0.0100015,0.0875254,0.112609],"study_design_scores_gemma":[0.0003166853,0.0006528216,0.5607433,0.0003227996,0.0008600915,0.0008892279,0.001159656,0.216649,0.05315003,0.01427698,0.1507894,0.0001901053],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5696062,0.002553344,0.01388455,0.0006023183,0.00009769018,0.0001088314,0.4074211,0.002262425,0.003463487],"genre_scores_gemma":[0.3294495,0.0008457141,0.02478295,0.0002523742,0.00003303766,0.0002710694,0.6429715,0.0001766876,0.001217225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006175231,"threshold_uncertainty_score":0.01227856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009166445863195722,"score_gpt":0.2380695717089343,"score_spread":0.2289031258457386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}