{"id":"W4318217771","doi":"10.1101/2023.01.23.23284864","title":"Germline pathogenic variants in 786 neuroblastoma patients","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Damon Runyon Cancer Research Foundation; Children’s Oncology Group; National Cancer Institute; National Institutes of Health; Children's Hospital of Philadelphia; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Germline; Neuroblastoma; Genetics; Biology; Computational biology; Cancer research; Gene; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001556224,0.0001773827,0.0002963174,0.0005549997,0.0003695403,0.0002260689,0.0001804404,0.0002380834,0.003008967],"category_scores_gemma":[0.00104985,0.0001404389,0.0001468319,0.0007148161,0.0001970649,0.000108515,0.0002592376,0.0001626906,0.0003362805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001861652,"about_ca_system_score_gemma":0.0001798324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003998768,"about_ca_topic_score_gemma":0.004429928,"domain_scores_codex":[0.9997652,0.00002409801,0.00002533816,0.00008340676,0.00007209084,0.00002979041],"domain_scores_gemma":[0.9996756,0.00007052268,0.0001289232,0.00003084176,0.00003027392,0.00006382005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002441597,0.00001684594,0.9880839,0.00002556516,0.00002534332,0.001416974,0.0001312517,0.00008591926,0.004776571,0.00004123355,0.000282284,0.004869961],"study_design_scores_gemma":[0.00003149366,0.0001604307,0.9853253,0.00002312374,0.00004048466,0.01078383,0.0002306365,0.0003279268,0.00137154,0.0000932952,0.001602881,0.000009130335],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985017,0.0002073563,0.00007221662,0.00001292657,0.000003024815,0.000007038583,0.0008879746,0.000005566703,0.0003022647],"genre_scores_gemma":[0.9986793,0.0001766942,0.0001835763,0.00001070708,0.000003925413,0.00001109747,0.0007434574,0.000002710242,0.0001884135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003998768,"threshold_uncertainty_score":0.01006597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03967665585869923,"score_gpt":0.3103773438979879,"score_spread":0.2707006880392887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}