{"id":"W4318225130","doi":"10.1136/svn-2022-002084","title":"Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis (INSPIRES)","year":2023,"lang":"en","type":"article","venue":"Stroke and Vascular Neurology","topic":"Cerebrovascular and Carotid Artery Diseases","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China; National Institute for Health and Care Research; Sanofi","keywords":"Medicine; Clopidogrel; Atorvastatin; Aspirin; Placebo; Clinical endpoint; Statin; Stroke (engine); Internal medicine; Randomized controlled trial; Anesthesia; Cardiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003724112,0.0002718719,0.000862299,0.0001148079,0.0001472283,0.00002674152,0.00007288904,0.0001050311,0.00001338599],"category_scores_gemma":[0.0001073273,0.0001349537,0.0001440747,0.0001204432,0.00030267,0.00008092207,0.00003749331,0.0001830367,2.40323e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004365711,"about_ca_system_score_gemma":0.00008470462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009815689,"about_ca_topic_score_gemma":0.00007833222,"domain_scores_codex":[0.998387,0.0003292996,0.0003462195,0.0003920381,0.0002911729,0.0002542174],"domain_scores_gemma":[0.9983396,0.0009486407,0.0002208782,0.0002185844,0.0001746605,0.00009766498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8899092,0.0001251422,0.1039863,0.00009275331,0.001899663,0.000008231115,0.0005295728,0.00007343817,0.001983306,0.000003144717,0.00003715712,0.001352114],"study_design_scores_gemma":[0.8167702,0.04301056,0.1348388,0.00005032285,0.001883448,0.00002759297,0.00008889419,0.001227212,0.001881068,0.000003908462,0.00004033351,0.0001776564],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914629,0.00005340749,0.001368219,0.00005156058,0.0001411688,0.006623155,0.000275357,0.00002319753,0.000001052226],"genre_scores_gemma":[0.9985592,0.0006315817,0.0001380104,0.00005785391,0.0001560287,0.0003135951,0.00009575714,0.00003608255,0.00001191197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07313905,"threshold_uncertainty_score":0.5503253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02497636887817797,"score_gpt":0.2600539412745331,"score_spread":0.2350775723963551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}