{"id":"W4318225130","doi":"10.1136/svn-2022-002084","title":"Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis (INSPIRES)","year":2023,"lang":"en","type":"article","venue":"Stroke and Vascular Neurology","topic":"Cerebrovascular and Carotid Artery Diseases","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China; National Institute for Health and Care Research; Sanofi","keywords":"Medicine; Clopidogrel; Atorvastatin; Aspirin; Placebo; Clinical endpoint; Statin; Stroke (engine); Internal medicine; Randomized controlled trial; Anesthesia; Cardiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06327675,0.005705298,0.007396587,0.001791275,0.002733888,0.002771067,0.004253254,0.00802667,0.03155934],"category_scores_gemma":[0.0366114,0.003167288,0.003988948,0.001641138,0.007224127,0.002629692,0.001639509,0.006655517,0.008902666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002137727,"about_ca_system_score_gemma":0.01042122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009720358,"about_ca_topic_score_gemma":0.001673645,"domain_scores_codex":[0.9492187,0.03895687,0.00225755,0.004381783,0.003227272,0.001957787],"domain_scores_gemma":[0.983147,0.00712142,0.002143248,0.002199378,0.002400689,0.00298824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8337768,0.01516122,0.003692484,0.02413235,0.00253987,0.0008287866,0.0006841178,0.003800617,0.005066288,0.02999734,0.02035668,0.05996329],"study_design_scores_gemma":[0.8411781,0.06547652,0.004177934,0.00347072,0.002561121,0.0003206426,0.0001669124,0.004522231,0.001290592,0.01685559,0.05970206,0.0002775724],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"methods","genre_scores_codex":[0.01062992,0.003366349,0.01359947,0.002886195,0.004007905,0.9590497,0.002238489,0.0002312128,0.003990851],"genre_scores_gemma":[0.0199505,0.0007413412,0.02055085,0.003187169,0.0006519045,0.9529679,0.0004885543,0.00001490017,0.001446753],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.06327675,"threshold_uncertainty_score":0.3346435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02497636887817797,"score_gpt":0.2600539412745331,"score_spread":0.2350775723963551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}