{"id":"W4318253712","doi":"10.1038/s41416-023-02154-9","title":"Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation","year":2023,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Medical Research Council; Newcastle University; Cancer Research UK; Pathological Society of Great Britain and Ireland; JGW Patterson Foundation; National Health and Medical Research Council; Johns Hopkins University; George Washington University","keywords":"Biology; Cancer research; Gene knockdown; Hedgehog signaling pathway; Immunohistochemistry; Downregulation and upregulation; Hepatocellular carcinoma; In vivo; Signal transduction; Gene; Genetics; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002194985,0.00007125802,0.0001818288,0.00002313174,0.00006149357,0.00001444702,0.0001660027,0.00006248792,0.0001603443],"category_scores_gemma":[0.00002806925,0.00003034982,0.0001788314,0.0003911936,0.00003042397,0.0000663744,0.00001675607,0.0001292194,0.000001254717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005426873,"about_ca_system_score_gemma":0.00005458316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001559329,"about_ca_topic_score_gemma":0.001001057,"domain_scores_codex":[0.9990331,0.00008970115,0.0003679923,0.00009592805,0.000278288,0.0001349967],"domain_scores_gemma":[0.9994593,0.00005399365,0.0002901734,0.00003743525,0.0001172059,0.00004190635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008507457,0.0000612096,0.1259014,0.00000636325,0.00001080098,0.000009292812,0.0001155036,0.0006627117,0.8317267,0.00001231698,0.00002679937,0.04138182],"study_design_scores_gemma":[0.0002772232,0.000401342,0.8337475,0.0003589223,0.000009889967,0.0000228966,0.00007278814,0.0004363869,0.1635618,0.000887376,0.0001689924,0.00005489372],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979656,0.001494799,9.102523e-7,0.0001190357,0.00004648616,0.0001991045,0.0001065945,0.00000484311,0.0000626603],"genre_scores_gemma":[0.9995321,0.0002710978,0.00001290689,0.000005405128,0.0001353362,0.00001164953,0.000009448735,0.000001310573,0.00002076535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7078461,"threshold_uncertainty_score":0.235725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01604390631549314,"score_gpt":0.231639922575584,"score_spread":0.2155960162600909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}