{"id":"W4318273619","doi":"10.1016/j.jcyt.2022.12.005","title":"Transplant for non-malignant disorders: an International Society for Cell & Gene Therapy Stem Cell Engineering Committee report on the role of alternative donors, stem cell sources and graft engineering","year":2023,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Stem cell; Medicine; Curative treatment; Hematopoietic stem cell transplantation; Transplantation; Hematopoietic stem cell; Intensive care medicine; Haematopoiesis; Genetic enhancement; Regimen; Oncology; Surgery; Internal medicine; Biology; Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005143159,0.0002840782,0.0003631129,0.0001167243,0.00008682386,0.00003412418,0.0002035317,0.0001131311,0.000007719222],"category_scores_gemma":[0.000001922572,0.0002149691,0.0002682341,0.0001354108,0.00003510521,0.00007182334,0.000007717336,0.000132744,0.00000195454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004292632,"about_ca_system_score_gemma":0.00004307095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002774861,"about_ca_topic_score_gemma":0.000006183111,"domain_scores_codex":[0.9985398,0.00001887867,0.0004483911,0.0003906925,0.0002945349,0.0003077156],"domain_scores_gemma":[0.9987304,0.0005774971,0.0001799461,0.0003380721,0.00008119982,0.00009294851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006548651,0.0004201127,0.008826101,0.0008450258,0.000414054,0.00001208343,0.02771882,0.003876388,0.9537579,0.0001698624,0.0001115981,0.003193213],"study_design_scores_gemma":[0.004309068,0.0006681769,0.001923167,0.0002413142,0.00008250031,0.00002708952,0.001744979,0.04641501,0.9338844,0.00006773866,0.01030934,0.0003271984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9629289,0.0003821501,0.03415361,0.0002589608,0.000215301,0.00166734,0.0002133986,0.0001008799,0.00007949152],"genre_scores_gemma":[0.991957,0.002901117,0.003782654,0.00008946754,0.000187129,0.00039098,0.0002257768,0.0001050992,0.0003607967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04253862,"threshold_uncertainty_score":0.8766184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01838750771338351,"score_gpt":0.2482497068760694,"score_spread":0.2298621991626859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}