{"id":"W4318302179","doi":"10.1016/s2352-3026(22)00377-5","title":"Emicizumab in people with moderate or mild haemophilia A (HAVEN 6): a multicentre, open-label, single-arm, phase 3 study","year":2023,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Hospices Civils de Lyon; F. Hoffmann-La Roche","keywords":"Medicine; Open label; Haemophilia; Physical therapy; Pediatrics; Internal medicine; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001840812,0.0009814972,0.001842863,0.0002342428,0.0004365811,0.0007754475,0.0004984926,0.001362052,0.004224228],"category_scores_gemma":[0.001139941,0.0004446221,0.001648372,0.000250213,0.000799959,0.0009864268,0.0003976277,0.002236626,0.0007935952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004057155,"about_ca_system_score_gemma":0.0005843863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007742444,"about_ca_topic_score_gemma":0.001956547,"domain_scores_codex":[0.9995042,0.0002718732,0.00002011127,0.00006405787,0.00004791367,0.00009185987],"domain_scores_gemma":[0.9994379,0.0001347796,0.0001313485,0.00003643402,0.00003092283,0.0002286043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9196525,0.01777706,0.004177203,0.0009208805,0.001538941,0.0001342659,0.0002054723,0.000380074,0.007542565,0.0001778684,0.001718441,0.04577493],"study_design_scores_gemma":[0.8410363,0.139619,0.01614351,0.00007484684,0.0007286156,0.0001608665,0.00006132653,0.0002895403,0.0004506817,0.000180059,0.00122268,0.00003258267],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925646,0.00357209,0.0003662403,0.0004047369,0.0001439445,0.001023281,0.0005349978,0.00004195693,0.001348068],"genre_scores_gemma":[0.9910535,0.002291295,0.001207926,0.0009952126,0.0001735287,0.001271702,0.0005908444,0.00001441712,0.002401622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004224228,"threshold_uncertainty_score":0.01413149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1899997733047888,"score_gpt":0.4239973036752933,"score_spread":0.2339975303705045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}