{"id":"W4318316239","doi":"10.1186/s40164-023-00375-5","title":"Depletion of polyfunctional CD26highCD8+ T cells repertoire in chronic lymphocytic leukemia","year":2023,"lang":"en","type":"article","venue":"Experimental Hematology and Oncology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Cytotoxic T cell; CD8; Immunology; Perforin; Chronic lymphocytic leukemia; TIGIT; Interleukin 21; T cell; Granzyme B; Cytokine; Biology; Cancer research; Medicine; Immune system; Leukemia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000112419,0.0001751358,0.0001471246,0.0003693619,0.0001371867,0.0001688228,0.00009078759,0.0001376884,0.001709026],"category_scores_gemma":[0.00009976017,0.00009164673,0.00009277415,0.0001959549,0.0001575276,0.00009937573,0.0001656901,0.0001474254,0.000228131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001598572,"about_ca_system_score_gemma":0.00007642276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004120786,"about_ca_topic_score_gemma":0.0004435572,"domain_scores_codex":[0.9999007,0.00002047693,0.00000901528,0.00002658349,0.00001472905,0.00002844188],"domain_scores_gemma":[0.9999241,0.00001305723,0.00002339598,0.000009183534,0.000007429297,0.00002295458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001075815,0.00008205408,0.01957884,0.00007866097,0.00000930944,0.0001784737,0.00004844151,0.00006811332,0.9724865,0.00005344175,0.00009535858,0.006245025],"study_design_scores_gemma":[0.0002366972,0.004903268,0.5725557,0.00005252307,0.0001243422,0.007153444,0.0003637908,0.002509324,0.4013189,0.0002893566,0.01047321,0.00001949492],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985502,0.0006931255,0.0003210118,0.00001326152,0.000002888698,0.000007366593,0.00009940349,0.00001272469,0.0003000103],"genre_scores_gemma":[0.9988354,0.0002524631,0.0002240728,0.00002501629,0.000006387751,0.00001855301,0.000186815,0.000004109813,0.0004471549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001709026,"threshold_uncertainty_score":0.005717218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01336960342260839,"score_gpt":0.278852581952666,"score_spread":0.2654829785300576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}