{"id":"W4318393621","doi":"10.1080/15548627.2023.2172873","title":"PRKN/parkin-mediated mitophagy is induced by the probiotics <i>Saccharomyces boulardii</i> and <i>Lactococcus lactis</i>","year":2023,"lang":"en","type":"article","venue":"Autophagy","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lallemand (Canada); University of Toronto","funders":"Canadian Institutes of Health Research; Mitacs","keywords":"Mitophagy; Biology; Parkin; Mitochondrion; Autophagy; Saccharomyces boulardii; Cell biology; Probiotic; Pharmacology; Parkinson's disease; Biochemistry; Disease; Genetics; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002181972,0.0003576211,0.0004465733,0.0001195107,0.0002542935,0.00008887231,0.0001744249,0.0002210867,0.0001313399],"category_scores_gemma":[0.00009142788,0.0002476464,0.0001406208,0.0005872472,0.00009832236,0.0001296283,0.0001284146,0.0002997465,0.0005139846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007038796,"about_ca_system_score_gemma":0.0001398054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007347173,"about_ca_topic_score_gemma":0.000005939105,"domain_scores_codex":[0.9980054,0.00008466374,0.0003126508,0.0005736245,0.0004396477,0.000583957],"domain_scores_gemma":[0.998733,0.0001831789,0.0001374525,0.0005374281,0.00007474318,0.0003342303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009698074,0.001830386,0.01800041,0.0006260608,0.003091826,0.002025324,0.002494179,0.00000218405,0.6461487,0.0006363919,0.275314,0.04886067],"study_design_scores_gemma":[0.008553782,0.001097368,0.1201975,0.0001769505,0.000907908,0.0001925115,0.0003036184,0.0007259762,0.4245543,0.0009816855,0.4415553,0.000753005],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909793,0.002008579,0.00001161166,0.003215874,0.000404851,0.001276777,0.0002350782,0.0004227269,0.001445191],"genre_scores_gemma":[0.9922908,0.0004329397,0.00007505871,0.003717686,0.0001427766,0.0001750694,0.0001962459,0.00006739035,0.002902025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2215944,"threshold_uncertainty_score":0.9999976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817096082220667,"score_gpt":0.2663026534608565,"score_spread":0.2481316926386498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}