{"id":"W4318407569","doi":"10.1101/2023.01.27.525928","title":"Haploid androgenetic development in bovines reveals imbalanced WNT signaling and impaired cell fate differentiation","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Science and Technology Research Partnership for Sustainable Development; CHIST-ERA; Natural Sciences and Engineering Research Council of Canada; Universidad de La Frontera; Fundação de Amparo à Pesquisa do Estado de São Paulo; Agencia Nacional de Investigación y Desarrollo; Agenția Națională pentru Cercetare și Dezvoltare","keywords":"Wnt signaling pathway; Biology; SOX2; Homeobox protein NANOG; Transcriptome; Blastocyst; Embryo; Embryogenesis; AXIN2; Blastula; Genetics; Andrology; Embryonic stem cell; Cell biology; Gastrulation; Signal transduction; Gene; Induced pluripotent stem cell; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001459646,0.000162782,0.0002246454,0.0004177974,0.0001781423,0.0003392462,0.0001152678,0.0002160215,0.001030725],"category_scores_gemma":[0.0001059953,0.0001650658,0.0002165257,0.0001817881,0.0002088234,0.00008818453,0.0001427409,0.0003133164,0.0002437134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002557244,"about_ca_system_score_gemma":0.0001532803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002604265,"about_ca_topic_score_gemma":0.003474516,"domain_scores_codex":[0.999796,0.0000199107,0.00001667518,0.00006780445,0.00006063871,0.0000389415],"domain_scores_gemma":[0.9998379,0.00002637933,0.00007148346,0.00001417385,0.00001449864,0.00003545839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005186816,0.000004665001,0.000604068,0.00002453759,0.000004471108,0.00006081544,0.00001969707,0.0000213511,0.9986264,0.00001673136,0.0000146913,0.000550707],"study_design_scores_gemma":[0.00001854018,0.0003270239,0.174636,0.00002912824,0.00006431152,0.001397449,0.0002672335,0.00104918,0.8153374,0.00008697033,0.006769828,0.00001696036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923552,0.002637915,0.002504254,0.00006006139,0.00001808114,0.00001666628,0.001434031,0.00006767338,0.0009059953],"genre_scores_gemma":[0.9923863,0.0009844789,0.001874014,0.00007578942,0.00000699984,0.00002186129,0.001436328,0.00003943714,0.003174695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002604265,"threshold_uncertainty_score":0.005178154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01383777313007434,"score_gpt":0.2125720093010378,"score_spread":0.1987342361709634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}