{"id":"W4318453049","doi":"10.1101/2023.01.28.525917","title":"SARS-CoV-2 M <sup>pro</sup> protease variants of concern display altered viral and host target processing but retain potency towards antivirals","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"SLAC National Accelerator Laboratory; Natural Sciences and Engineering Research Council of Canada; Basic Energy Sciences; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Office of Science; Fundacja na rzecz Nauki Polskiej; Government of Alberta; U.S. Department of Energy; Alberta Innovates; Biological and Environmental Research; National Institutes of Health","keywords":"Protease; Potency; Proteolysis; Mutant; Viral replication; Biology; Virulence; Virology; Mutation; Cleavage (geology); Secretion; Virus; Biochemistry; In vitro; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001286673,0.000270628,0.0002047163,0.00009158714,0.0000784097,0.0002385665,0.000139066,0.0002458887,0.001075162],"category_scores_gemma":[0.0001435498,0.00007886691,0.0002215585,0.0001202944,0.0001539917,0.0001228263,0.00009214156,0.0004051729,0.000272447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001710514,"about_ca_system_score_gemma":0.00009354827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004118516,"about_ca_topic_score_gemma":0.0004098948,"domain_scores_codex":[0.9998595,0.0000337286,0.00001491872,0.00001965624,0.00003943051,0.00003281563],"domain_scores_gemma":[0.9999266,0.00001764685,0.00002259427,0.00001149199,0.000008028166,0.00001371019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002556381,0.00003779865,0.0007256424,0.00001425492,0.000009124212,0.00008795677,0.00001058262,0.0001540146,0.9978071,0.00006472871,0.00005278828,0.000780388],"study_design_scores_gemma":[0.00001805845,0.0004527526,0.007697377,0.000002276073,0.00001183341,0.0006790978,0.00002362003,0.001026154,0.9888014,0.00003509269,0.001248236,0.00000414707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984864,0.0002361235,0.0005236081,0.00002909049,0.000008252592,0.000006019213,0.0002557668,0.00001477886,0.000439988],"genre_scores_gemma":[0.9975006,0.00008959785,0.0007072409,0.00002741873,0.000004411902,0.000005107876,0.0007141532,0.00001199379,0.0009395615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001075162,"threshold_uncertainty_score":0.003596723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02981240309786441,"score_gpt":0.258803151066228,"score_spread":0.2289907479683636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}