{"id":"W4318475110","doi":"10.3389/fonc.2023.976945","title":"Development and validation of an advanced ex vivo brain slice invasion assay to model glioblastoma cell invasion into the complex brain microenvironment","year":2023,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Ex vivo; Slice preparation; Pathology; In vivo; Confocal microscopy; Biology; Glioma; Neuroscience; Central nervous system; Cell biology; Medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006221103,0.0001583563,0.0002278599,0.000311647,0.0001517841,0.00001910325,0.0003750871,0.00007461929,0.000004114814],"category_scores_gemma":[0.0003405709,0.000135164,0.00002256678,0.0006243662,0.0001295499,0.000231855,0.0002981229,0.0001615812,0.00001027238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001889228,"about_ca_system_score_gemma":0.00006353566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006295305,"about_ca_topic_score_gemma":0.00003703218,"domain_scores_codex":[0.9983321,0.0002346146,0.0003268196,0.0005195383,0.0002572949,0.0003296357],"domain_scores_gemma":[0.9992213,0.000318643,0.0001020303,0.0002399641,0.000008680579,0.0001093636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007750585,0.0000612348,0.0000791111,0.00001706701,5.601918e-7,0.00001610471,0.003337325,0.03088316,0.9435109,0.00002351261,0.002008683,0.01998485],"study_design_scores_gemma":[0.0004511987,0.0003608931,0.0006446163,0.00001512462,0.000001943087,0.000006637137,0.0005426243,0.0898413,0.8910555,0.0001386075,0.01680422,0.0001373197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907629,0.000009320575,0.005621365,0.002635451,0.000370215,0.0004432029,0.000003363492,0.00004812259,0.000106063],"genre_scores_gemma":[0.9772796,0.00006364899,0.01879986,0.003421453,0.00001531942,0.00005492836,0.000003639006,0.00002366231,0.0003378617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05895815,"threshold_uncertainty_score":0.5511827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03387237527968791,"score_gpt":0.2814983879439254,"score_spread":0.2476260126642375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}