{"id":"W4318476835","doi":"10.3390/brainsci13020218","title":"Amyloid-PET and White Matter Hyperintensities Have Independent Effects on Baseline Cognitive Function and Synergistic Effects on Longitudinal Executive Function","year":2023,"lang":"en","type":"article","venue":"Brain Sciences","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Hyperintensity; Dementia; Psychology; Cognition; Internal medicine; Mediation; Effects of sleep deprivation on cognitive performance; Alzheimer's Disease Neuroimaging Initiative; Moderation; Neuroimaging; Alzheimer's disease; Cardiology; Neuroscience; Medicine; Disease; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00333227,0.0009851936,0.0005147539,0.0005033787,0.0003282586,0.0007767344,0.0005123363,0.0006692171,0.001622258],"category_scores_gemma":[0.006415376,0.0004219902,0.001070313,0.0004005622,0.0004222375,0.0006380532,0.0009886638,0.0009152932,0.0001922422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002778142,"about_ca_system_score_gemma":0.000646324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003949751,"about_ca_topic_score_gemma":0.005283248,"domain_scores_codex":[0.9986981,0.0006805643,0.00006733764,0.0002292776,0.000139795,0.0001848442],"domain_scores_gemma":[0.9968444,0.001480481,0.0007292203,0.0004878792,0.0001866454,0.0002713039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002285396,0.0003171781,0.9849748,0.00002940943,0.001355016,0.0001928073,0.0004206137,0.0004633906,0.003179622,0.0001319254,0.00009744542,0.006552394],"study_design_scores_gemma":[0.00001637427,0.0004076438,0.997144,0.00000672368,0.0003704482,0.0001275604,0.0001040778,0.000751281,0.0007177608,0.0002100689,0.0001385764,0.000005439423],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989379,0.000231477,0.0003448197,0.00004403496,0.000005699279,0.000006899365,0.0001308628,0.000009354035,0.0002889014],"genre_scores_gemma":[0.9992802,0.00004762456,0.0002087359,0.00001025631,0.000004757597,0.000010379,0.0001057899,0.000003067245,0.0003293024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003949751,"threshold_uncertainty_score":0.01762295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02178032148276515,"score_gpt":0.3027163987618285,"score_spread":0.2809360772790634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}