{"id":"W4318478893","doi":"10.3390/vaccines11020275","title":"Development of an In Vitro Test Method to Replace an Animal-Based Potency Test for Pertactin Antigen in Multivalent Vaccines","year":2023,"lang":"en","type":"article","venue":"Vaccines","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto; Western University; Sanofi (Canada)","funders":"Sanofi","keywords":"Antigenicity; Potency; Pertactin; Epitope; In vivo; In vitro; Diphtheria; Antigen; Monoclonal antibody; Antibody; Virology; In vitro toxicology; Medicine; Immunology; Biology; Vaccination; Biotechnology; Pertussis toxin; Biochemistry; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008002947,0.000261957,0.0004873713,0.0007156039,0.0001389605,0.0000183082,0.0002386354,0.0002056689,0.0001105889],"category_scores_gemma":[0.0006989063,0.0002296684,0.00006699578,0.0008524517,0.000006846263,0.0001835252,0.00007114637,0.0001314665,0.00004316011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005270957,"about_ca_system_score_gemma":0.0001305472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008155622,"about_ca_topic_score_gemma":0.002639522,"domain_scores_codex":[0.9981675,0.0001518601,0.0006801623,0.00052693,0.00002316598,0.0004504359],"domain_scores_gemma":[0.9986013,0.0006932727,0.0001471008,0.0003542426,0.0001571786,0.00004696159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009531738,0.000756386,0.06152285,0.00005154364,0.00001808871,0.000001811173,0.0006704319,0.00006198241,0.9203449,0.00000513226,0.0001462704,0.01546743],"study_design_scores_gemma":[0.001824298,0.0004528131,0.4190515,0.00004287931,0.00000875806,0.000006894222,0.0004236636,0.0003259652,0.5709324,0.00001119099,0.006711659,0.0002079998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979172,0.0000683324,0.0002401597,0.0004564462,0.0003260555,0.0007574059,0.00008430354,0.0001288505,0.00002119603],"genre_scores_gemma":[0.9770155,0.00001101833,0.02187679,0.00004878293,0.00006491354,0.0002421745,0.0003006902,0.00004063307,0.0003995117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3575286,"threshold_uncertainty_score":0.9365608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03186488002990921,"score_gpt":0.3280492793189821,"score_spread":0.2961843992890729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}