{"id":"W4318478893","doi":"10.3390/vaccines11020275","title":"Development of an In Vitro Test Method to Replace an Animal-Based Potency Test for Pertactin Antigen in Multivalent Vaccines","year":2023,"lang":"en","type":"article","venue":"Vaccines","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto; Western University; Sanofi (Canada)","funders":"Sanofi","keywords":"Antigenicity; Potency; Pertactin; Epitope; In vivo; In vitro; Diphtheria; Antigen; Monoclonal antibody; Antibody; Virology; In vitro toxicology; Medicine; Immunology; Biology; Vaccination; Biotechnology; Pertussis toxin; Biochemistry; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006503807,0.001801573,0.001016983,0.001578219,0.0003795084,0.001162721,0.001352908,0.00150776,0.001424689],"category_scores_gemma":[0.006468351,0.0007901445,0.0007899078,0.0006938024,0.0007769439,0.0009173899,0.001013314,0.001668686,0.001620992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005929735,"about_ca_system_score_gemma":0.0009760872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00102756,"about_ca_topic_score_gemma":0.001518015,"domain_scores_codex":[0.992078,0.004034905,0.0005850382,0.0008141871,0.002215977,0.000271921],"domain_scores_gemma":[0.9944015,0.001959722,0.0008867322,0.0009691624,0.001566894,0.0002160366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001312471,0.0001887187,0.001906388,0.0002368828,0.00003628011,0.00006970216,0.00007263302,0.0003768818,0.9824015,0.0003088553,0.0001819374,0.01408891],"study_design_scores_gemma":[0.00001215998,0.00120302,0.002439645,0.00004802814,0.00009334174,0.0003667874,0.00005593882,0.002807815,0.9881068,0.000173938,0.00466537,0.000027293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2441704,0.008219155,0.732729,0.0006545125,0.001032081,0.002102066,0.001164054,0.001831413,0.008097307],"genre_scores_gemma":[0.4232099,0.005532814,0.5552731,0.0008553877,0.0003229235,0.001952053,0.001927247,0.0003012707,0.01062533],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.006503807,"threshold_uncertainty_score":0.03439581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03186488002990921,"score_gpt":0.3280492793189821,"score_spread":0.2961843992890729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}