{"id":"W4318479211","doi":"10.3390/v15020360","title":"SKI-1/S1P Facilitates SARS-CoV-2 Spike Induced Cell-to-Cell Fusion via Activation of SREBP-2 and Metalloproteases, Whereas PCSK9 Enhances the Degradation of ACE2","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Furin; Proprotein Convertases; Cell fusion; Cell biology; Proprotein convertase; Cell; Lipid bilayer fusion; Metalloproteinase; Chemistry; Ectodomain; Fusion protein; HEK 293 cells; Biology; LDL receptor; Receptor; Biochemistry; Cholesterol; Recombinant DNA; Matrix metalloproteinase; Lipoprotein; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005195051,0.0001907819,0.0003429678,0.0003397298,0.000101243,0.00002759946,0.0001793788,0.000113948,0.00001380052],"category_scores_gemma":[0.0003702328,0.0001323314,0.00008434812,0.0008789342,0.0001234466,0.0002190994,0.000132053,0.0001734793,0.00007556958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003938534,"about_ca_system_score_gemma":0.0001504601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002907485,"about_ca_topic_score_gemma":0.0001042356,"domain_scores_codex":[0.9983003,0.0001281625,0.0003839487,0.0003283199,0.000600217,0.0002590203],"domain_scores_gemma":[0.9988194,0.0003794901,0.000173239,0.0003806681,0.000215042,0.00003213223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003778021,0.0001632561,0.004725521,0.0003258927,0.00003966764,0.000002812085,0.0006947977,8.943504e-7,0.9855549,0.00001940434,0.0003236098,0.007771417],"study_design_scores_gemma":[0.0007582561,0.0004861131,0.005183749,0.0001195639,0.00005469874,0.000001672009,0.0007082739,0.0001385785,0.9811853,0.0001475145,0.01109364,0.0001226865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976557,0.0003275764,0.0001892962,0.0002457562,0.0000640132,0.0008999865,0.00002307224,0.00006788738,0.0005267041],"genre_scores_gemma":[0.996783,0.00004088989,0.0001639136,0.002769079,0.00004404641,0.00007586047,0.00001051588,0.00002421387,0.00008853754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01077003,"threshold_uncertainty_score":0.5396319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07910546669166003,"score_gpt":0.3523000492974394,"score_spread":0.2731945826057794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}