{"id":"W4318479211","doi":"10.3390/v15020360","title":"SKI-1/S1P Facilitates SARS-CoV-2 Spike Induced Cell-to-Cell Fusion via Activation of SREBP-2 and Metalloproteases, Whereas PCSK9 Enhances the Degradation of ACE2","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Furin; Proprotein Convertases; Cell fusion; Cell biology; Proprotein convertase; Cell; Lipid bilayer fusion; Metalloproteinase; Chemistry; Ectodomain; Fusion protein; HEK 293 cells; Biology; LDL receptor; Receptor; Biochemistry; Cholesterol; Recombinant DNA; Matrix metalloproteinase; Lipoprotein; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001227655,0.0004143938,0.0003589381,0.0001794936,0.0001299104,0.0003299595,0.0001259841,0.0002295584,0.001325653],"category_scores_gemma":[0.00009145788,0.0001450826,0.0003805712,0.000119596,0.0001828763,0.0002225377,0.0002229217,0.0005499337,0.0005178272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002634347,"about_ca_system_score_gemma":0.0002582481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006616972,"about_ca_topic_score_gemma":0.0009161221,"domain_scores_codex":[0.9998307,0.0000276004,0.00001940365,0.00002248929,0.00004443021,0.00005523558],"domain_scores_gemma":[0.9999005,0.00001919653,0.0000282473,0.00001286426,0.00001038615,0.0000288564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001476655,0.00003592027,0.0001066567,0.00002091545,0.000003330709,0.00002665193,0.00000979851,0.0000264269,0.9990776,0.00004232159,0.00002698105,0.0004757741],"study_design_scores_gemma":[0.00001562063,0.000219341,0.003158362,0.000002227798,0.000007281134,0.0001416264,0.0000196057,0.0006473101,0.9948589,0.00001903424,0.0009080697,0.000002738797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969745,0.0007306617,0.001013345,0.00007711518,0.0000222392,0.00001831894,0.0002750813,0.00005036919,0.0008383916],"genre_scores_gemma":[0.995133,0.0004549088,0.001138896,0.00004395724,0.00001044618,0.00002594259,0.0007974629,0.00001468087,0.00238061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325653,"threshold_uncertainty_score":0.004434824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07910546669166003,"score_gpt":0.3523000492974394,"score_spread":0.2731945826057794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}