{"id":"W4318479953","doi":"10.3390/pharmaceutics15020435","title":"On the Physical Stability of Leucine-Containing Spray-Dried Powders for Respiratory Drug Delivery","year":2023,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Spray drying; Active ingredient; Leucine; Mannitol; Amorphous solid; Chemical engineering; Chemistry; Supercritical fluid; Dry-powder inhaler; Materials science; Chromatography; Trehalose; Gelatin; Inhaler; Organic chemistry; Pharmacology; Biochemistry; Medicine; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003585233,0.0002145125,0.0001996709,0.0002051706,0.0001772156,0.0002147075,0.0001287618,0.0001816916,0.0009137104],"category_scores_gemma":[0.0005446668,0.00009909923,0.0002670104,0.0001599772,0.000187006,0.0002493333,0.0001199301,0.0003391128,0.0002180426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002305045,"about_ca_system_score_gemma":0.0001518408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009385385,"about_ca_topic_score_gemma":0.001041556,"domain_scores_codex":[0.9997714,0.00004582125,0.0000175049,0.0000480477,0.00009110106,0.00002618946],"domain_scores_gemma":[0.9997209,0.00009044971,0.00006637511,0.00002212124,0.00008197732,0.00001815484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001475703,0.00002454056,0.0003680069,0.00003640235,0.00000886829,0.00002826026,0.00003115912,0.0001042338,0.9961284,0.00002053671,0.00001997408,0.003081926],"study_design_scores_gemma":[0.00001254574,0.001106452,0.01010463,0.000008089723,0.0000319473,0.0001521298,0.00003196275,0.001271477,0.9862655,0.00001614557,0.0009908122,0.000008311331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945648,0.002519259,0.002080202,0.0000328605,0.00001812638,0.00003037541,0.0001054325,0.00001847624,0.0006304488],"genre_scores_gemma":[0.9954535,0.001178069,0.002377672,0.00002617374,0.00001088011,0.0000231479,0.0002136079,0.00001917585,0.0006976692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009385385,"threshold_uncertainty_score":0.003056645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1285667416993395,"score_gpt":0.3774104328353778,"score_spread":0.2488436911360383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}