{"id":"W4318482017","doi":"10.1128/aac.01409-22","title":"Biochemical Insights into Imipenem Collateral Susceptibility Driven by <i>ampC</i> Mutations Conferring Ceftolozane/Tazobactam Resistance in Pseudomonas aeruginosa","year":2023,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Pseudomonas aeruginosa; Imipenem; Microbiology; Biology; Tazobactam; Collateral damage; Virology; Medicine; Antibiotic resistance; Antibiotics; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007509745,0.0002084432,0.0001472201,0.0001122492,0.00008768818,0.000258337,0.0001331559,0.0002404438,0.0006716727],"category_scores_gemma":[0.0001423087,0.0001147249,0.0001659399,0.0001092623,0.0001714026,0.0001429955,0.00009188483,0.0004093274,0.0002916761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001923052,"about_ca_system_score_gemma":0.000128484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009500065,"about_ca_topic_score_gemma":0.0009671288,"domain_scores_codex":[0.9999437,0.00001073935,0.000006456918,0.000008709423,0.0000198899,0.00001044127],"domain_scores_gemma":[0.9999254,0.00001282754,0.00002659659,0.000007081539,0.00001013362,0.00001803254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002936068,0.000008459441,0.0002174548,0.0000130395,0.00000233109,0.0000876431,0.000009930559,0.00009948308,0.9991334,0.00007147725,0.000009468218,0.0003177738],"study_design_scores_gemma":[0.000006109816,0.00008434478,0.008535758,0.000004070958,0.00000911352,0.0006458433,0.00006850973,0.002461905,0.9872273,0.0001124313,0.0008356408,0.000009143911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967093,0.0003453243,0.00181412,0.0001202711,0.000007808973,0.000005870411,0.0001810836,0.00003765422,0.0007784578],"genre_scores_gemma":[0.9977958,0.0002120985,0.001421631,0.00002216409,0.000002388192,0.000003968451,0.0001596314,0.00001146315,0.0003708381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009500065,"threshold_uncertainty_score":0.002247036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007641424586784069,"score_gpt":0.2495719317541747,"score_spread":0.2419305071673906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}