{"id":"W4318483914","doi":"10.1158/2767-9764.crc-22-0456","title":"Integrated, Longitudinal Analysis of Cell-free DNA in Uveal Melanoma","year":2023,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; Government of Ontario; Princess Margaret Cancer Foundation","keywords":"Epigenomics; Melanoma; DNA sequencing; Cell-free fetal DNA; CDKN2A; Oncology; Computational biology; Medicine; Biology; Cancer research; Internal medicine; DNA; Cancer; Gene; DNA methylation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006677529,0.00007434083,0.0001621132,0.0005379855,0.0001112306,0.00002158208,0.001279558,0.0000773636,0.00004654994],"category_scores_gemma":[0.0003286556,0.00007822626,0.00009226872,0.002433329,0.000268004,0.000003008121,0.001101758,0.0002205756,0.0000105499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008965613,"about_ca_system_score_gemma":0.0003881434,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002565559,"about_ca_topic_score_gemma":0.02552627,"domain_scores_codex":[0.9989337,0.0001633743,0.0002268311,0.0002147567,0.0001927452,0.0002686071],"domain_scores_gemma":[0.9973978,0.0001932213,0.00004949949,0.001979155,0.0003101087,0.00007021085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002170332,0.0005124593,0.3099885,0.0000753641,0.001014463,0.00000946106,0.0008046881,0.004685607,0.6181938,0.004558328,0.05191147,0.00802887],"study_design_scores_gemma":[0.00266399,0.0006306859,0.5505744,0.0001241744,0.0004380895,0.00000182793,0.002671917,0.01466722,0.1728155,0.001973695,0.2527305,0.0007079918],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909003,0.003191519,0.00006855826,0.001339629,0.00003872098,0.000178664,0.0004513567,0.000008747576,0.003822445],"genre_scores_gemma":[0.9831568,0.01527969,0.0003231668,0.00002379782,0.00003111627,0.0001958426,0.0005827943,0.00001311697,0.0003936685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4453783,"threshold_uncertainty_score":0.9922553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09865593293251709,"score_gpt":0.4082315612715743,"score_spread":0.3095756283390572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}