{"id":"W4318483914","doi":"10.1158/2767-9764.crc-22-0456","title":"Integrated, Longitudinal Analysis of Cell-free DNA in Uveal Melanoma","year":2023,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; Government of Ontario; Princess Margaret Cancer Foundation","keywords":"Epigenomics; Melanoma; DNA sequencing; Cell-free fetal DNA; CDKN2A; Oncology; Computational biology; Medicine; Biology; Cancer research; Internal medicine; DNA; Cancer; Gene; DNA methylation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009344946,0.00021199,0.0003021859,0.0007357657,0.0001797822,0.0004579801,0.0001970061,0.0002744201,0.000605325],"category_scores_gemma":[0.001943024,0.0001366734,0.0002371265,0.000599627,0.0002246118,0.0002765384,0.0003751431,0.0003852558,0.0001965198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002992155,"about_ca_system_score_gemma":0.0002360406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001477415,"about_ca_topic_score_gemma":0.002372759,"domain_scores_codex":[0.9996481,0.00009300448,0.00002087466,0.0001258097,0.00007652311,0.00003567912],"domain_scores_gemma":[0.9990264,0.0003154551,0.0003052053,0.0001021469,0.000159493,0.00009129017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009337494,0.0001370086,0.6345066,0.0001232401,0.00025321,0.0002126726,0.0003043638,0.002914513,0.3207403,0.0002201376,0.0001568751,0.03949742],"study_design_scores_gemma":[0.00003023113,0.001022056,0.8205717,0.00003350046,0.0002816654,0.001568978,0.0002351595,0.02387013,0.1497284,0.0006582486,0.001953701,0.00004628662],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987683,0.0007562971,0.01078009,0.00004176739,0.000005306493,0.00001770293,0.0004970044,0.00005731007,0.0001615291],"genre_scores_gemma":[0.9932941,0.000153243,0.0057938,0.00003200125,0.00000564301,0.00001839673,0.0005135874,0.00001062506,0.0001785731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001477415,"threshold_uncertainty_score":0.004942179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09865593293251709,"score_gpt":0.4082315612715743,"score_spread":0.3095756283390572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}