{"id":"W4318484507","doi":"10.1039/d2bm00819j","title":"Subcutaneous delivery of an antibody against SARS-CoV-2 from a supramolecular hydrogel depot","year":2023,"lang":"en","type":"article","venue":"Biomaterials Science","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chemistry, Engineering and Medicine for Human Health, Stanford University; Stanford Maternal and Child Health Research Institute; Stanford Bio-X; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Bill and Melinda Gates Foundation; National Defense Science and Engineering Graduate; U.S. Department of Defense; National Institutes of Health; National Science Foundation","keywords":"Depot; Antibody; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Chemistry; Coronavirus disease 2019 (COVID-19); Supramolecular chemistry; 2019-20 coronavirus outbreak; Subcutaneous injection; Virology; Nanotechnology; Medicine; Immunology; Biology; Materials science; Bioinformatics; Pathology; Molecule; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001781892,0.0004765774,0.0001898882,0.0001812241,0.00008899985,0.0001877786,0.000161469,0.0002889197,0.001040537],"category_scores_gemma":[0.0001196143,0.0001037371,0.0002151787,0.0001361951,0.0001692882,0.000248276,0.00009546643,0.0005023698,0.0002097849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002465286,"about_ca_system_score_gemma":0.0002223316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004828051,"about_ca_topic_score_gemma":0.0008538105,"domain_scores_codex":[0.9998953,0.000010031,0.000006487454,0.00003355118,0.00002583807,0.00002873462],"domain_scores_gemma":[0.9998673,0.00003687086,0.00004402922,0.00001433046,0.000008552883,0.00002889581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007559913,0.00005922367,0.00004020783,0.00001858878,0.000003235268,0.00001647895,0.000005328036,0.0001159882,0.9982362,0.00002910395,0.00002312099,0.001377022],"study_design_scores_gemma":[0.00001262377,0.0007533347,0.0005236153,0.000001693941,0.000006781997,0.0000487723,0.000003443471,0.0008781492,0.9973871,0.00001380334,0.0003680666,0.000002560045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830163,0.0009087126,0.01353898,0.00009340853,0.00008410107,0.0001343695,0.0004390111,0.0001681519,0.001616917],"genre_scores_gemma":[0.9861806,0.0004815819,0.01032108,0.00006679337,0.00001985937,0.00008627003,0.0002682292,0.00003552474,0.002539985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001040537,"threshold_uncertainty_score":0.003480971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068828596533266,"score_gpt":0.3067891281867232,"score_spread":0.2861008422213905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}