{"id":"W4318484507","doi":"10.1039/d2bm00819j","title":"Subcutaneous delivery of an antibody against SARS-CoV-2 from a supramolecular hydrogel depot","year":2023,"lang":"en","type":"article","venue":"Biomaterials Science","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chemistry, Engineering and Medicine for Human Health, Stanford University; Stanford Maternal and Child Health Research Institute; Stanford Bio-X; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Bill and Melinda Gates Foundation; National Defense Science and Engineering Graduate; U.S. Department of Defense; National Institutes of Health; National Science Foundation","keywords":"Depot; Antibody; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Chemistry; Coronavirus disease 2019 (COVID-19); Supramolecular chemistry; 2019-20 coronavirus outbreak; Subcutaneous injection; Virology; Nanotechnology; Medicine; Immunology; Biology; Materials science; Bioinformatics; Pathology; Molecule; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005927613,0.0001268324,0.0001575101,0.00008407758,0.0001220668,0.00006172623,0.0005598381,0.00009540862,0.000007370902],"category_scores_gemma":[0.0001497079,0.0001199714,0.00005207334,0.0003953969,0.000521568,0.00001438283,0.0001874271,0.00001340971,0.00003750041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001284883,"about_ca_system_score_gemma":0.000188876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002126177,"about_ca_topic_score_gemma":0.00002132569,"domain_scores_codex":[0.9985352,0.00007409009,0.0002898806,0.0005469308,0.0002685413,0.000285337],"domain_scores_gemma":[0.9989998,0.000008110009,0.0001165524,0.0006728166,0.0001290018,0.00007369327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006019197,0.00005241292,0.0002606383,0.000009293648,0.000006372377,0.00001639192,0.00003415304,0.000003230194,0.9987683,0.00002530702,0.00001358768,0.0007500864],"study_design_scores_gemma":[0.0001568845,0.0001396269,0.003434747,0.000007245385,0.000004492741,0.000009474805,0.00002841789,0.0002980317,0.9950252,0.0001395117,0.0006088283,0.0001475158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989051,0.0001326512,0.0001553572,0.00003041442,0.0002381526,0.0002048268,0.0001858005,0.00005393015,0.0000938059],"genre_scores_gemma":[0.9985793,0.00006138332,0.0008594241,0.0001017585,0.00004946228,0.00001226669,0.0003187853,0.00001162612,0.000006006467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003743111,"threshold_uncertainty_score":0.4892293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068828596533266,"score_gpt":0.3067891281867232,"score_spread":0.2861008422213905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}