{"id":"W4318539492","doi":"10.1093/ecco-jcc/jjac190.0017","title":"OP17 Upadacitinib Improves Endoscopic Outcomes in Patients with Moderate to Severely Active Crohn’s Disease Irrespective of Previous Failure to Respond to Biologics or Conventional Therapies","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Internal medicine; Placebo; Adverse effect; Crohn's disease; Population; Gastroenterology; Abdominal pain; Statistical significance; Clinical trial; Randomized controlled trial; Surgery; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009396923,0.0004022369,0.001233563,0.0002659365,0.0002462605,0.000569852,0.0002074872,0.0003128928,0.001597521],"category_scores_gemma":[0.001057857,0.0001284749,0.0008846422,0.0002801378,0.0002440415,0.0003491321,0.0002958302,0.0004542291,0.0001572522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002589691,"about_ca_system_score_gemma":0.0004554772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004994624,"about_ca_topic_score_gemma":0.001556004,"domain_scores_codex":[0.999625,0.0001710865,0.0000512456,0.00004872581,0.00003701071,0.00006686759],"domain_scores_gemma":[0.9992414,0.0001793617,0.0002380548,0.00003715527,0.00006026894,0.0002439242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5570539,0.005570628,0.286305,0.001402551,0.003951985,0.0005096851,0.0001416576,0.0006781762,0.01233307,0.00008840131,0.002523294,0.1294416],"study_design_scores_gemma":[0.06335807,0.1484751,0.7739662,0.0002649345,0.003760691,0.001068344,0.0002289986,0.002088793,0.003629404,0.0001747978,0.00293448,0.00005014554],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955284,0.003321527,0.00006698623,0.0001002632,0.0000281956,0.00009638514,0.0001945222,0.000009356943,0.0006542131],"genre_scores_gemma":[0.9987092,0.0004639158,0.0001291058,0.0001183726,0.00003960682,0.00005054212,0.0003019385,0.000001353451,0.0001858432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001597521,"threshold_uncertainty_score":0.005344272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00929440255155273,"score_gpt":0.2600089938344227,"score_spread":0.2507145912828699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}