{"id":"W4318539599","doi":"10.1093/ecco-jcc/jjac190.0707","title":"P577 A Phase 1b Study to Evaluate Safety, Tolerability, Pharmacokinetics and Clinical Efficacy of the Nucleotide-binding oligomerization domain, Leucine rich Repeat containing X1 (NLRX1) agonist NX-13 in Ulcerative Colitis","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Ulcerative colitis; Medicine; Pharmacokinetics; Adverse effect; Tolerability; Internal medicine; Prednisone; Clinical trial; Pharmacology; Gastroenterology; Placebo; Phases of clinical research; Clinical endpoint; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001572041,0.001276991,0.001741475,0.0003766451,0.0003934741,0.0006662758,0.0007099434,0.001410014,0.006928034],"category_scores_gemma":[0.0008761479,0.0004988479,0.000823784,0.0002585815,0.001032755,0.0007195039,0.0003021245,0.002786017,0.001285412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005457399,"about_ca_system_score_gemma":0.001477343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004928049,"about_ca_topic_score_gemma":0.0009176544,"domain_scores_codex":[0.9995468,0.0002117744,0.00002624317,0.00008047147,0.00005288451,0.00008182372],"domain_scores_gemma":[0.9993506,0.0001473863,0.0001131581,0.00006024368,0.00005653771,0.0002719992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7718004,0.0742494,0.00185803,0.0008693234,0.0005404829,0.0003508156,0.000146342,0.001120951,0.08623213,0.0003262915,0.003676778,0.05882913],"study_design_scores_gemma":[0.4234509,0.5665395,0.002635372,0.00003090084,0.0001547105,0.0001411197,0.00002115516,0.0006063095,0.005125746,0.0001400468,0.001139921,0.00001419871],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910665,0.001974989,0.0007142023,0.0005030732,0.000140531,0.002662713,0.0009113015,0.0001280575,0.001898609],"genre_scores_gemma":[0.9817499,0.001563772,0.002007112,0.0008654162,0.0001863034,0.004210835,0.002053704,0.00004022995,0.00732263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006928034,"threshold_uncertainty_score":0.02317655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02132207396103842,"score_gpt":0.3489543984651094,"score_spread":0.327632324504071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}