{"id":"W4318539744","doi":"10.1093/ecco-jcc/jjac190.0127","title":"DOP87 The Anti-TL1A Antibody PRA023 Demonstrated Proof-of-Concept in Crohn’s Disease: Phase 2a APOLLO-CD Study Results","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Crohn's disease; Internal medicine; Placebo; Population; Clinical endpoint; Ulcerative colitis; Surrogate endpoint; Inflammatory bowel disease; Disease; Hepatology; Gastroenterology; Clinical trial; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002650259,0.0007279384,0.001146532,0.0002396334,0.0002623108,0.00102563,0.0004968035,0.0009792307,0.003677738],"category_scores_gemma":[0.001089766,0.0002759836,0.0009931481,0.0002183336,0.000378388,0.0003916242,0.0002878285,0.002265634,0.0009612673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004770464,"about_ca_system_score_gemma":0.001019528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004283134,"about_ca_topic_score_gemma":0.001070434,"domain_scores_codex":[0.9994056,0.0003073302,0.00002759727,0.00006760877,0.0001013468,0.00009036085],"domain_scores_gemma":[0.9993155,0.0001754141,0.0001263352,0.00006488829,0.00009861011,0.0002191348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3447777,0.06670724,0.01043197,0.00377303,0.002788909,0.0007833175,0.0003725276,0.005158136,0.2039911,0.001288696,0.03462147,0.3253059],"study_design_scores_gemma":[0.3709323,0.5206076,0.02677432,0.0002439725,0.001584718,0.001335264,0.00009826885,0.005179902,0.03406963,0.0007510599,0.03835743,0.00006557901],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681641,0.0101413,0.003732487,0.001671929,0.0002951091,0.003115429,0.00471567,0.0003623297,0.007801505],"genre_scores_gemma":[0.972544,0.003811532,0.005695459,0.002519568,0.0002558005,0.002826633,0.00606999,0.00009018446,0.00618699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003677738,"threshold_uncertainty_score":0.01401609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01300696470343075,"score_gpt":0.3036264385807754,"score_spread":0.2906194738773447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}