{"id":"W4318539744","doi":"10.1093/ecco-jcc/jjac190.0127","title":"DOP87 The Anti-TL1A Antibody PRA023 Demonstrated Proof-of-Concept in Crohn’s Disease: Phase 2a APOLLO-CD Study Results","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Crohn's disease; Internal medicine; Placebo; Population; Clinical endpoint; Ulcerative colitis; Surrogate endpoint; Inflammatory bowel disease; Disease; Hepatology; Gastroenterology; Clinical trial; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006774539,0.0001804538,0.0002791048,0.000123649,0.000114844,0.0000650399,0.0002440095,0.00008467126,0.00001236239],"category_scores_gemma":[0.0002595714,0.000133394,0.0001336954,0.0002653261,0.0002058107,0.00002006442,0.00009943596,0.0001756593,0.000001576105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001504107,"about_ca_system_score_gemma":0.0003924494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002168692,"about_ca_topic_score_gemma":0.00005522598,"domain_scores_codex":[0.9981952,0.0002357193,0.0007259861,0.0002396169,0.0002958722,0.0003076093],"domain_scores_gemma":[0.9988058,0.00003631453,0.0004248121,0.0002702241,0.0002501711,0.0002127069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1677146,0.01626866,0.4690244,0.001019032,0.003246041,0.1077769,0.01051216,0.003036583,0.05822754,0.0007920925,0.05395696,0.108425],"study_design_scores_gemma":[0.004766688,0.0004645951,0.987605,0.00008698698,0.00008223948,0.00004479647,0.001131983,0.0001235873,0.003921623,0.0000872876,0.001521063,0.0001641939],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979413,0.0006168255,0.00003030824,0.0003043381,0.0001795831,0.0005503915,0.0002221128,0.000006851115,0.0001482889],"genre_scores_gemma":[0.9992305,0.0001501376,0.00001198662,0.00007861215,0.0002307958,0.00001480104,0.00004361136,0.00002007804,0.0002194663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5185806,"threshold_uncertainty_score":0.543965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01300696470343075,"score_gpt":0.3036264385807754,"score_spread":0.2906194738773447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}