{"id":"W4318539756","doi":"10.1093/ecco-jcc/jjac190.0566","title":"P436 Efficacy and safety of intravenous ustekinumab re-induction therapy in Crohn’s disease patients with secondary loss of response to ustekinumab maintenance therapy: Week 16 results from the POWER trial","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Ustekinumab; Clinical endpoint; Maintenance therapy; Crohn's disease; Placebo; Randomization; Internal medicine; Adverse effect; Gastroenterology; Randomized controlled trial; Clinical trial; Surgery; Disease; Adalimumab; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002571862,0.00112732,0.002654712,0.0002471549,0.0002386534,0.001470013,0.0006837802,0.001267188,0.00650476],"category_scores_gemma":[0.002868301,0.000429824,0.002332892,0.0003246419,0.000979459,0.001251093,0.000565966,0.002972481,0.001105999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004325156,"about_ca_system_score_gemma":0.0006304143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002592274,"about_ca_topic_score_gemma":0.0003907167,"domain_scores_codex":[0.9988753,0.0006454985,0.00006963656,0.0001520469,0.0001068233,0.0001506537],"domain_scores_gemma":[0.9985241,0.0004601068,0.0004081738,0.0001403032,0.0001149147,0.0003524713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9242231,0.004235196,0.001904218,0.00118977,0.00230758,0.0001030858,0.00009941199,0.0006090347,0.005066094,0.0001833831,0.00273554,0.05734361],"study_design_scores_gemma":[0.7893083,0.1920087,0.01172818,0.0001619095,0.001620413,0.0002245624,0.00004682137,0.0008684084,0.00110806,0.000551841,0.002342593,0.00003019021],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786513,0.01238171,0.0009248825,0.001233752,0.0003746898,0.001234487,0.0009064662,0.0001791182,0.00411341],"genre_scores_gemma":[0.990477,0.002757888,0.0006781906,0.0008870371,0.0003832504,0.001254226,0.000962357,0.00003300319,0.002567091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00650476,"threshold_uncertainty_score":0.02176064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008690169345820925,"score_gpt":0.2330663173029089,"score_spread":0.224376147957088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}