{"id":"W4318539850","doi":"10.1093/ecco-jcc/jjac190.0547","title":"P417 Frequent Early Nocebo Complaints but Maintained Clinical Efficacy, Biomarker and Therapeutic drug levels following mandatory Biosimilar Switch in Patients with Inflammatory Bowel disease: Preliminary data from a Prospective Observational Cohort Study","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Biosimilar; Infliximab; Adalimumab; Internal medicine; Inflammatory bowel disease; Ulcerative colitis; Nocebo; Adverse effect; Faecal calprotectin; Observational study; Therapeutic drug monitoring; Nocebo Effect; Crohn's disease; Calprotectin; Prospective cohort study; Clinical trial; Disease; Placebo; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001770931,0.0002393634,0.0005847213,0.0001561544,0.0001879391,0.00006597389,0.0003171002,0.0001526472,0.00006427496],"category_scores_gemma":[0.0001877022,0.000172919,0.00009631476,0.0001725386,0.0003175056,0.0002136343,0.0002935128,0.0004463938,0.000004028481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005497827,"about_ca_system_score_gemma":0.0001574265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000508555,"about_ca_topic_score_gemma":0.00004280226,"domain_scores_codex":[0.997537,0.0006256008,0.0008387799,0.0004696892,0.0002039635,0.000324993],"domain_scores_gemma":[0.9983145,0.0007188872,0.0003357983,0.0003404872,0.0001582329,0.0001321049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007634191,0.0006681869,0.9877388,0.00001662927,0.001136492,0.000289144,0.0001812262,4.589322e-7,0.00003850236,0.00003036532,0.0004658671,0.001800113],"study_design_scores_gemma":[0.006511641,0.0007331196,0.9908898,0.0001855796,0.0004145043,0.000007989162,0.0002848383,0.00005261055,0.00001502841,0.000443534,0.0002419018,0.0002194811],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969222,0.000934706,0.00003548023,0.0004443682,0.0003221934,0.0008318563,0.0004803133,0.00001682085,0.00001204592],"genre_scores_gemma":[0.9992454,0.00007779612,0.0001822525,0.0002630231,0.0000482972,0.00001195103,0.00007487351,0.00002050778,0.00007591039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003150948,"threshold_uncertainty_score":0.7051433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05769409734213311,"score_gpt":0.3315514839756188,"score_spread":0.2738573866334857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}