{"id":"W4318539850","doi":"10.1093/ecco-jcc/jjac190.0547","title":"P417 Frequent Early Nocebo Complaints but Maintained Clinical Efficacy, Biomarker and Therapeutic drug levels following mandatory Biosimilar Switch in Patients with Inflammatory Bowel disease: Preliminary data from a Prospective Observational Cohort Study","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Biosimilar; Infliximab; Adalimumab; Internal medicine; Inflammatory bowel disease; Ulcerative colitis; Nocebo; Adverse effect; Faecal calprotectin; Observational study; Therapeutic drug monitoring; Nocebo Effect; Crohn's disease; Calprotectin; Prospective cohort study; Clinical trial; Disease; Placebo; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009392425,0.0003717055,0.0005290169,0.0006197353,0.0005943632,0.001060092,0.0004523745,0.0006832604,0.002062262],"category_scores_gemma":[0.003180091,0.0003117753,0.00079708,0.001016826,0.0003500187,0.0006944957,0.0004832826,0.0009099728,0.0003271131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004500673,"about_ca_system_score_gemma":0.0004641115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004414309,"about_ca_topic_score_gemma":0.003492747,"domain_scores_codex":[0.9991189,0.0002102318,0.00009512078,0.0002502674,0.0001560032,0.0001694297],"domain_scores_gemma":[0.9955899,0.0007070485,0.002520291,0.0003107178,0.000326137,0.0005460641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007115972,0.00009048612,0.9975817,0.00001404776,0.00007290691,0.0001689087,0.00005628681,0.00001416724,0.0002173663,0.000006442231,0.00007124757,0.0009947632],"study_design_scores_gemma":[0.00005788986,0.0004330934,0.9984927,0.000007267891,0.00005372719,0.0004652559,0.0001021822,0.0001278789,0.00005552849,0.00001691448,0.0001813493,0.000006222577],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992816,0.0002171892,0.00004840313,0.00002336323,0.000005007774,0.00001182965,0.0002240451,0.000001485429,0.0001871271],"genre_scores_gemma":[0.9993591,0.00007687287,0.00004785009,0.00003279161,0.00001666327,0.00001145036,0.0003558138,0.000001368156,0.00009819155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004414309,"threshold_uncertainty_score":0.008777261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05769409734213311,"score_gpt":0.3315514839756188,"score_spread":0.2738573866334857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}