{"id":"W4318540774","doi":"10.2139/ssrn.4341893","title":"Gene Knockout of NHX-3 in the Soil Nematode Caenorhabditis elegans Leads to Broad-Spectrum Compensatory Regulation of Na /H Exchangers, Antiporters, and the V-Type H -ATPase","year":2023,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Nematode management and characterization studies","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; RTDS Technologies (Canada); University of Manitoba","funders":"","keywords":"Caenorhabditis elegans; Antiporters; Gene; ATPase; Biology; Antiporter; Gene knockout; Cell biology; Nematode; Broad spectrum; Knockout mouse; Chemistry; Genetics; Enzyme; Biochemistry; Transporter; Ecology; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001345879,0.0001033217,0.0002194958,0.00004782172,0.0001977037,0.00003233894,0.0002286036,0.00003217082,0.00002135509],"category_scores_gemma":[0.00002481432,0.0000364876,0.00006145395,0.000662184,0.00009756841,0.00008362076,0.00006556427,0.0002370811,0.000004945256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003437716,"about_ca_system_score_gemma":0.00003283862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001947244,"about_ca_topic_score_gemma":0.003077293,"domain_scores_codex":[0.9986339,0.000149058,0.000301682,0.000128024,0.0002523414,0.0005350006],"domain_scores_gemma":[0.9995461,0.0001160843,0.0002018165,0.00006152249,0.00005121276,0.00002326921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001469858,0.0003168724,0.1418441,0.0001348294,0.0005602597,0.00002649803,0.01175688,0.0002504487,0.6290773,0.1435598,0.003852517,0.06715067],"study_design_scores_gemma":[0.001359272,0.0006295373,0.955201,0.00008476889,0.00008744108,0.0001004971,0.01522941,0.0002230985,0.005625283,0.01969135,0.001481546,0.000286843],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929072,0.0007801507,0.00002035335,0.005900374,0.00007043079,0.0002072407,0.00000535942,0.00001356423,0.00009532013],"genre_scores_gemma":[0.9961312,0.00328435,0.000002001869,0.0001646099,0.0001093723,0.000005589909,0.00001878452,0.000001615699,0.0002824849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8133568,"threshold_uncertainty_score":0.1717202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0129675502838609,"score_gpt":0.2195971738256288,"score_spread":0.2066296235417679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}