{"id":"W4318540774","doi":"10.2139/ssrn.4341893","title":"Gene Knockout of NHX-3 in the Soil Nematode Caenorhabditis elegans Leads to Broad-Spectrum Compensatory Regulation of Na /H Exchangers, Antiporters, and the V-Type H -ATPase","year":2023,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Nematode management and characterization studies","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; RTDS Technologies (Canada); University of Manitoba","funders":"","keywords":"Caenorhabditis elegans; Antiporters; Gene; ATPase; Biology; Antiporter; Gene knockout; Cell biology; Nematode; Broad spectrum; Knockout mouse; Chemistry; Genetics; Enzyme; Biochemistry; Transporter; Ecology; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175789,0.0005797924,0.000253251,0.0003213354,0.0002199498,0.0002776064,0.0003480364,0.0004522544,0.001214029],"category_scores_gemma":[0.0001256426,0.0002526659,0.0003378874,0.0001278099,0.0005119399,0.0002218058,0.000300325,0.0007191522,0.0002991942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004253695,"about_ca_system_score_gemma":0.0003644731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001775933,"about_ca_topic_score_gemma":0.004703624,"domain_scores_codex":[0.9998393,0.00001041541,0.00001806889,0.00004374614,0.00005142565,0.0000370433],"domain_scores_gemma":[0.9996935,0.00003956207,0.0001106321,0.00002733312,0.00002520947,0.0001037927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009621927,0.00001859239,0.0001007138,0.0000110782,0.000003745728,0.00006217617,0.000005805903,0.00003315727,0.9993694,0.00004509788,0.00001876246,0.0002351863],"study_design_scores_gemma":[0.00003432151,0.0001574528,0.008279473,0.00000713067,0.00002502023,0.0002596508,0.00005745975,0.001070674,0.9892977,0.0000745623,0.0007267033,0.00000973081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969876,0.0002053737,0.001330488,0.00007165844,0.00003333565,0.00001847637,0.0004074963,0.0001104717,0.0008351567],"genre_scores_gemma":[0.9946721,0.0001694961,0.001301217,0.00007795975,0.000004979144,0.0000223816,0.0004120731,0.00005707243,0.003282682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001775933,"threshold_uncertainty_score":0.004061341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0129675502838609,"score_gpt":0.2195971738256288,"score_spread":0.2066296235417679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}