{"id":"W4318578576","doi":"10.1371/journal.pcbi.1010847","title":"Tissue specific LRRK2 interactomes reveal a distinct striatal functional unit","year":2023,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; School of Pharmacy, University College London; Medical Research Council; National Institutes of Health; Università degli Studi di Padova; Parkinson's UK; University of Reading; University College London; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Multiple Sclerosis Society; Guarantors of Brain; Weston Brain Institute; Wellcome Trust; Alzheimer's Association; Biotechnology and Biological Sciences Research Council; Michael J. Fox Foundation for Parkinson's Research","keywords":"Interactome; LRRK2; Computational biology; Biology; Protein–protein interaction; Genetics; Mutation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006509096,0.0001537648,0.0002411265,0.0002103218,0.00009985055,0.00001395757,0.00006068052,0.000073629,0.0009079511],"category_scores_gemma":[0.00006092751,0.0001293022,0.0000746435,0.000296165,0.0000625354,0.00004333253,0.00006420555,0.0001132906,0.00191442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005887418,"about_ca_system_score_gemma":0.0001020156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008409017,"about_ca_topic_score_gemma":0.000001931198,"domain_scores_codex":[0.9989665,0.00005826259,0.0002190948,0.0003367681,0.0001880332,0.000231397],"domain_scores_gemma":[0.9992786,0.0002783164,0.00006775832,0.0001172037,0.0001149491,0.0001431644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005013936,0.005079006,0.6090779,0.0003511496,0.004523177,0.001956403,0.0005910013,0.001746541,0.03172719,0.07981204,0.06025228,0.1998693],"study_design_scores_gemma":[0.003181754,0.0005495576,0.9244367,0.00005763369,0.0001128296,0.00009100178,0.00005512295,0.0034031,0.001205231,0.01856529,0.04811442,0.0002273806],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938126,0.0001163885,0.002728176,0.001065208,0.0004318136,0.0002904062,0.0004244008,0.0002227786,0.0009082555],"genre_scores_gemma":[0.9905166,0.00001217627,0.001035201,0.0001893672,0.0003449148,0.00004336737,0.006758171,0.00001824381,0.001081934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3153588,"threshold_uncertainty_score":0.9988627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06632779322250902,"score_gpt":0.3164780709930718,"score_spread":0.2501502777705628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}