{"id":"W4318578576","doi":"10.1371/journal.pcbi.1010847","title":"Tissue specific LRRK2 interactomes reveal a distinct striatal functional unit","year":2023,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; School of Pharmacy, University College London; Medical Research Council; National Institutes of Health; Università degli Studi di Padova; Parkinson's UK; University of Reading; University College London; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Multiple Sclerosis Society; Guarantors of Brain; Weston Brain Institute; Wellcome Trust; Alzheimer's Association; Biotechnology and Biological Sciences Research Council; Michael J. Fox Foundation for Parkinson's Research","keywords":"Interactome; LRRK2; Computational biology; Biology; Protein–protein interaction; Genetics; Mutation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327159,0.0003083848,0.0003675759,0.0007445474,0.0002725334,0.0004501797,0.0001524558,0.0002674999,0.001783637],"category_scores_gemma":[0.0002233448,0.0001664547,0.0007308676,0.0006025973,0.0002173678,0.000243334,0.0005570159,0.0003461678,0.0003242596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002266871,"about_ca_system_score_gemma":0.0001924795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000993848,"about_ca_topic_score_gemma":0.003485734,"domain_scores_codex":[0.9998541,0.0000179757,0.000007674935,0.00005838618,0.00003680289,0.00002503129],"domain_scores_gemma":[0.9999082,0.00002124793,0.00002645609,0.00001632475,0.00001461433,0.00001310861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002895384,0.00002085639,0.01186547,0.0003026614,0.0002039702,0.0004589873,0.0001452439,0.00297204,0.9704162,0.001440738,0.0003491032,0.01153518],"study_design_scores_gemma":[0.00004487796,0.0004095154,0.5403831,0.00007483702,0.0007327663,0.004529461,0.0006242804,0.05182524,0.3764641,0.007455131,0.0173767,0.00008010875],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969431,0.0006799349,0.02463331,0.00006521629,0.000007461217,0.00002909832,0.002510342,0.0002966778,0.00234694],"genre_scores_gemma":[0.9691215,0.000587361,0.02313852,0.00005288201,0.000004822035,0.00005057667,0.005414098,0.0001118748,0.001518348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001783637,"threshold_uncertainty_score":0.005966842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06632779322250902,"score_gpt":0.3164780709930718,"score_spread":0.2501502777705628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}