{"id":"W4318579858","doi":"10.1093/ecco-jcc/jjac190.0760","title":"P630 Upadacitinib Improves Clinical Outcomes in Patients with Moderate to Severely Active Crohn’s Disease Irrespective of Previous Failure to Respond to Biologics or Conventional Therapies","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Adverse effect; Internal medicine; Clinical trial; Gastroenterology; Crohn's disease; Placebo; Maintenance therapy; Randomized controlled trial; Phases of clinical research; Surgery; Disease; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007644347,0.0002960525,0.001037076,0.0002060654,0.0002442615,0.0004145532,0.0001836,0.0003148564,0.001539727],"category_scores_gemma":[0.0009913964,0.0001320251,0.0007787439,0.0002436467,0.0002653659,0.0002904941,0.0002829204,0.0004728315,0.0001520277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000239482,"about_ca_system_score_gemma":0.0004099833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000439185,"about_ca_topic_score_gemma":0.00115577,"domain_scores_codex":[0.9996487,0.0001604282,0.00004859341,0.00004662659,0.00003523227,0.00006033561],"domain_scores_gemma":[0.999406,0.0001471009,0.0001648218,0.00002886155,0.00003277318,0.0002205296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7089065,0.007434478,0.1355463,0.001134352,0.002662304,0.0004941204,0.0001329766,0.001007493,0.02506219,0.0001062347,0.001763587,0.1157495],"study_design_scores_gemma":[0.1039985,0.2940716,0.589042,0.0001908499,0.002597224,0.001006647,0.0001751079,0.001869469,0.003933942,0.0002708176,0.002799606,0.00004423702],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965488,0.002274907,0.00009029594,0.0001031882,0.00003208232,0.0001067495,0.000160774,0.000009827518,0.0006734701],"genre_scores_gemma":[0.9990588,0.0003311817,0.0001065182,0.0001016003,0.00004059354,0.00004966135,0.0001565648,8.795673e-7,0.000154251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001539727,"threshold_uncertainty_score":0.005150914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01505798885519538,"score_gpt":0.2978377736744603,"score_spread":0.2827797848192649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}