{"id":"W4318579866","doi":"10.1093/ecco-jcc/jjac190.0732","title":"P602 Achievement of stringent histologic and composite endpoints in subjects with moderately to severely active ulcerative colitis treated with etrasimod: a post hoc analysis of the phase 3 ELEVATE UC 52 and ELEVATE UC 12 trials","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Post-hoc analysis; Medicine; Ulcerative colitis; Gastroenterology; Clinical endpoint; Internal medicine; Post hoc; Placebo; Surgery; Clinical trial; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007245025,0.001528775,0.00364833,0.0003819926,0.000398255,0.00117912,0.0006480677,0.001198722,0.005283256],"category_scores_gemma":[0.003735269,0.0004896629,0.004221603,0.0004126042,0.0009899074,0.001085371,0.0007171825,0.002311133,0.0006002769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004376078,"about_ca_system_score_gemma":0.001129796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004710832,"about_ca_topic_score_gemma":0.001353563,"domain_scores_codex":[0.9960119,0.002916067,0.0002283876,0.0003445189,0.0001969712,0.0003020858],"domain_scores_gemma":[0.9957247,0.002034957,0.000962077,0.0003868509,0.0003281793,0.0005632009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9863132,0.001717586,0.001471412,0.0003491129,0.00211792,0.00003167018,0.00002928125,0.0002527341,0.003147467,0.00004137892,0.0004891788,0.004038983],"study_design_scores_gemma":[0.5208969,0.433885,0.03101067,0.00008560237,0.006882104,0.00009860404,0.0001049961,0.001567129,0.002954396,0.0003167001,0.002136404,0.00006139994],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887052,0.003250313,0.0007056532,0.0003491861,0.0002681417,0.002580682,0.001809006,0.00006588042,0.00226605],"genre_scores_gemma":[0.9924387,0.0007185143,0.0008687547,0.0003516762,0.0002633926,0.002254323,0.00124673,0.0000238123,0.001834119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007245025,"threshold_uncertainty_score":0.03831577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01756587722205432,"score_gpt":0.2749331421350383,"score_spread":0.257367264912984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}