{"id":"W4318580158","doi":"10.1093/ecco-jcc/jjac190.0040","title":"OP40 PRA023 Demonstrated Efficacy and Favorable Safety as Induction Therapy for Moderately to Severely Active UC: Phase 2 ARTEMIS-UC Study Results","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Calgary","funders":"","keywords":"Medicine; Internal medicine; Clinical endpoint; Ulcerative colitis; Placebo; Rituximab; Adverse effect; Gastroenterology; Clinical trial; Surgery; Disease; Pathology; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002161006,0.000807878,0.001466271,0.0002130175,0.0002447025,0.00066191,0.000423514,0.0006239788,0.003789616],"category_scores_gemma":[0.001243343,0.0002332648,0.001153838,0.0002367257,0.0003922396,0.0003884445,0.0002642915,0.001397101,0.0005905185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002605094,"about_ca_system_score_gemma":0.0008875689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002881698,"about_ca_topic_score_gemma":0.000876235,"domain_scores_codex":[0.9993587,0.0003712359,0.00004632519,0.00008220107,0.00007596348,0.00006552815],"domain_scores_gemma":[0.9992187,0.0001776532,0.0002131095,0.00007996455,0.00008683986,0.0002236762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6603152,0.02510283,0.01173492,0.001848772,0.003214041,0.0004593722,0.0001865321,0.00209756,0.1390104,0.000310542,0.005050702,0.1506692],"study_design_scores_gemma":[0.4387284,0.4588692,0.06753466,0.0001007476,0.003283525,0.0008459835,0.00005561102,0.002464963,0.01924247,0.0003914548,0.008411311,0.00007181401],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855188,0.004849808,0.001794679,0.0005190787,0.000079376,0.002207038,0.002737912,0.0002302993,0.002062832],"genre_scores_gemma":[0.9896356,0.001407975,0.002441902,0.0005960632,0.0001164372,0.001031291,0.002814882,0.00003159592,0.001924204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003789616,"threshold_uncertainty_score":0.01267749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253877843196028,"score_gpt":0.3160550411916284,"score_spread":0.2935162627596681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}