{"id":"W4318580171","doi":"10.1093/ecco-jcc/jjac190.0678","title":"P548 Efficacy outcomes of placebo maintenance treatment in patients with moderate to severe Crohn’s disease who responded to placebo induction therapy: Post-hoc analysis of the Phase 3 ADVANCE, MOTIVATE, and FORTIFY Risankizumab Studies","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University Health Centre","funders":"","keywords":"Medicine; Placebo; Post-hoc analysis; Internal medicine; Clinical trial; Maintenance therapy; Gastroenterology; Crohn's disease; Clinical endpoint; Abdominal pain; Disease; Surgery; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006921086,0.001037091,0.003086179,0.0004242284,0.000281247,0.0009904999,0.0007494972,0.000945497,0.003266311],"category_scores_gemma":[0.006065304,0.0003458998,0.004887562,0.0003749016,0.0006589963,0.001030803,0.0007208775,0.001909707,0.0003761049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005495439,"about_ca_system_score_gemma":0.0006684825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003452795,"about_ca_topic_score_gemma":0.0005411119,"domain_scores_codex":[0.9949661,0.003516549,0.0003221541,0.0004969566,0.0003271477,0.0003710736],"domain_scores_gemma":[0.9933652,0.004015509,0.001160784,0.0005646736,0.0003706797,0.0005231502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9566727,0.001758627,0.01940671,0.0003951447,0.007367522,0.00007823652,0.00007731369,0.0005250941,0.002776662,0.00006326555,0.0005676614,0.01031115],"study_design_scores_gemma":[0.2157543,0.475207,0.2807928,0.0001122402,0.01632776,0.0002265246,0.0002815016,0.004176725,0.00377952,0.0003975382,0.00284146,0.0001026499],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961907,0.001496894,0.0002924855,0.0001048429,0.00006908653,0.0003366214,0.0007541979,0.0000175264,0.0007375421],"genre_scores_gemma":[0.9975631,0.0001850174,0.0002889422,0.0001084005,0.00009253839,0.0004227921,0.0008864017,0.000007827949,0.0004448317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006921086,"threshold_uncertainty_score":0.03660262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01169062173904621,"score_gpt":0.2855315404617644,"score_spread":0.2738409187227182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}