{"id":"W4318580232","doi":"10.1093/ecco-jcc/jjac190.0714","title":"P584 Efficacy, safety, and tolerability of AMT-101, a gut selective oral IL-10 fusion, in the Phase 2 FILLMORE trial of patients with chronic pouchitis","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia; Mount Sinai Hospital; Western University","funders":"","keywords":"Pouchitis; Medicine; Ulcerative colitis; Internal medicine; Gastroenterology; Tolerability; Proctocolectomy; Randomized controlled trial; Surgery; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00217887,0.001295345,0.001819467,0.000333269,0.0003629202,0.0009436507,0.0006147197,0.001532122,0.004671244],"category_scores_gemma":[0.001132237,0.0005198266,0.0009891419,0.0002692721,0.0009616819,0.0009645356,0.0003112256,0.002287248,0.0006824834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000423661,"about_ca_system_score_gemma":0.0008329077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004678921,"about_ca_topic_score_gemma":0.001005353,"domain_scores_codex":[0.9994282,0.0003717657,0.00002130421,0.00005762261,0.0000401988,0.00008086162],"domain_scores_gemma":[0.9992687,0.0002367644,0.00014593,0.00003889736,0.00003736555,0.0002722801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.926147,0.02034065,0.001887594,0.0005658373,0.0005017237,0.0001467908,0.000106376,0.0006111934,0.0131337,0.0001240246,0.001520209,0.0349149],"study_design_scores_gemma":[0.7923191,0.202505,0.002780089,0.00002162418,0.0002086087,0.00007922282,0.00002341474,0.0006313111,0.0009079708,0.00006781634,0.0004425066,0.0000132836],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951376,0.001886609,0.0002092813,0.0004899394,0.0001372072,0.0006980195,0.0002995153,0.00006666609,0.001075189],"genre_scores_gemma":[0.9930611,0.001018082,0.0006808147,0.0006767985,0.0003392667,0.001566256,0.0004780819,0.00001387166,0.002165729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004671244,"threshold_uncertainty_score":0.01562685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006423856954021132,"score_gpt":0.255676525098537,"score_spread":0.2492526681445159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}