{"id":"W4318590674","doi":"10.1038/s41467-023-35979-2","title":"Influence of circadian clocks on adaptive immunity and vaccination responses","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Schweizerischen Gesellschaft für Endokrinologie und Diabetologie; Swiss Life Stiftung für Chancenreichtum und Zukunft; Fondation Novartis Consumer Health; Olga Mayenfisch Stiftung; International Max Planck Research School for Advanced Methods in Process and Systems Engineering; Novo Nordisk; Chica and Heinz Schaller Foundation; Vontobel-Stiftung; Université de Genève; Fondation Leenaards; European Foundation for the Study of Diabetes; École Polytechnique Fédérale de Lausanne; Deutsche Forschungsgemeinschaft; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation; National Science Foundation","keywords":"Immune system; Acquired immune system; Circadian rhythm; Lymph node; Immunity; Vaccination; Lymph; Biology; Immunology; Circadian clock; Medicine; Neuroscience; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002028703,0.0001419867,0.0001739003,0.00009400201,0.0001112099,0.000385053,0.0001142848,0.0001211471,0.0005988297],"category_scores_gemma":[0.0003728639,0.00007876604,0.0001910537,0.00006953065,0.0002097305,0.0002330241,0.0002131038,0.0001851232,0.00007352856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003583405,"about_ca_system_score_gemma":0.0002686285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001123519,"about_ca_topic_score_gemma":0.001324787,"domain_scores_codex":[0.9999306,0.00001775088,0.000003582032,0.0000205947,0.00001231017,0.00001522854],"domain_scores_gemma":[0.9999032,0.00002805558,0.00003713257,0.000009727148,0.000008700835,0.00001313558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001129941,0.00009834805,0.01511946,0.0002847266,0.0001064114,0.0002611152,0.0001439458,0.06492413,0.8551476,0.02924205,0.0007247752,0.03281749],"study_design_scores_gemma":[0.0002029395,0.001438393,0.1599206,0.0001040835,0.0002101354,0.0003308061,0.0003241532,0.5175947,0.2720857,0.02657624,0.02107259,0.0001396979],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.919482,0.003138043,0.06882482,0.0003924101,0.0002029233,0.00003049604,0.0004444594,0.0001407157,0.007344149],"genre_scores_gemma":[0.9968187,0.0007325055,0.001776182,0.00002881298,0.00001698987,0.00001484413,0.00004691004,0.00001231686,0.0005527952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001123519,"threshold_uncertainty_score":0.002599955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04306873018694255,"score_gpt":0.3255301784126244,"score_spread":0.2824614482256819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}