{"id":"W4318591663","doi":"10.22541/au.167514670.04452922/v1","title":"Hematopoietic Stem Cell Transplantation Based on Minimal Residual Disease with a Unified Conditioning Regimen Comprising Total Body Irradiation, Etoposide and Cyclophosphamide: Results from the JPLSG ALL-R08-II Trial, the First Nationwide Prospective Study for Children with Intermediate-Risk Relapsed Acute Lymphoblastic Leukemia in Japan","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre","funders":"","keywords":"Total body irradiation; Medicine; Etoposide; Minimal residual disease; Cyclophosphamide; Hematopoietic stem cell transplantation; Regimen; Internal medicine; Transplantation; Oncology; Surgery; Busulfan; Leukemia; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002450596,0.0007368908,0.001279687,0.0002600039,0.0002356327,0.0006021283,0.0005281168,0.000345755,0.0003830659],"category_scores_gemma":[0.0007129595,0.0002325943,0.001065793,0.0004156427,0.0005623737,0.0004442755,0.000490527,0.0009401346,0.0000906261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005095457,"about_ca_system_score_gemma":0.0008500926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009370602,"about_ca_topic_score_gemma":0.00225821,"domain_scores_codex":[0.9992448,0.0004150227,0.00007499457,0.0001015707,0.00008755321,0.00007601983],"domain_scores_gemma":[0.9992821,0.00008274437,0.0002247364,0.0001054534,0.00004085243,0.0002641708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3192639,0.01564602,0.4672269,0.001379035,0.006305144,0.0004071879,0.0007768191,0.004206141,0.04080759,0.0002845762,0.003105591,0.140591],"study_design_scores_gemma":[0.11551,0.2234786,0.6407272,0.0002100715,0.006225578,0.0009722218,0.0003359697,0.002066972,0.006213102,0.0001754485,0.004018991,0.00006574132],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983885,0.001014126,0.00009534723,0.00005029691,0.00001019033,0.00009762024,0.0001583398,0.000006672054,0.00017878],"genre_scores_gemma":[0.9973139,0.0005488795,0.0003264694,0.0001575975,0.00003471331,0.000144366,0.001377605,0.000006478807,0.0000899564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002450596,"threshold_uncertainty_score":0.0129602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337484583190384,"score_gpt":0.2601699407295262,"score_spread":0.2467950948976224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}