{"id":"W4318618155","doi":"10.1038/s41563-022-01464-2","title":"A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2","year":2023,"lang":"en","type":"article","venue":"Nature Materials","topic":"Respiratory viral infections research","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; School of Medicine, Indiana University; University of Illinois at Urbana-Champaign; University of California, Irvine; School of Medicine, Stanford University; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Stanford Bio-X; Howard Hughes Medical Institute","keywords":"Adjuvant; Immune system; Antigen; Virology; Influenza vaccine; TLR7; Biology; Heterologous; Antibody; Immunology; Epitope; Influenza A virus; Vaccination; Toll-like receptor; Virus; Innate immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001336569,0.0003103832,0.0001248147,0.0001877616,0.00009048991,0.0001700338,0.0001300622,0.0003192995,0.001314082],"category_scores_gemma":[0.00008267364,0.0001046359,0.0002134192,0.00004647874,0.0001105127,0.0001518263,0.0002199981,0.0003433386,0.0003920233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000150126,"about_ca_system_score_gemma":0.0001690288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001426972,"about_ca_topic_score_gemma":0.0003748648,"domain_scores_codex":[0.9999071,0.00001607729,0.000007036958,0.00001630203,0.00002947227,0.00002399676],"domain_scores_gemma":[0.9999522,0.000009780684,0.00000955817,0.000004141868,0.00001201144,0.00001228829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004009105,0.00003823655,0.00004052767,0.00002401222,0.000002073472,0.00001375664,0.000002788957,0.00007948771,0.9986542,0.00005358977,0.00004341186,0.001007703],"study_design_scores_gemma":[0.00001798351,0.0005545842,0.0003980336,0.000006210793,0.000009642859,0.0001111493,0.000007748292,0.001406103,0.9958665,0.00003516081,0.001584215,0.000002685267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865502,0.001328438,0.008237503,0.0001751722,0.00008318366,0.00004678068,0.0001134304,0.00013657,0.00332877],"genre_scores_gemma":[0.9880546,0.0004709677,0.00768874,0.0001394007,0.00002174306,0.00003373305,0.0002271402,0.00002215663,0.00334141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001314082,"threshold_uncertainty_score":0.004396021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05665351146308186,"score_gpt":0.3946631468441026,"score_spread":0.3380096353810207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}