{"id":"W4318619600","doi":"10.1038/s41375-023-01833-z","title":"KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition","year":2023,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Science and Engineering Research Board; Canadian Cancer Society Research Institute; Israel Science Foundation; Indian Council of Medical Research; Varda and Boaz Dotan Research Center for Hemato-Oncology Research, Tel Aviv University; Council of Scientific and Industrial Research, India; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Synthetic lethality; Cancer research; Myeloid leukemia; DNA repair; Poly ADP ribose polymerase; Biology; NPM1; Leukemia; DNA damage; Histone; Epigenetics; Daunorubicin; Gene; Immunology; Genetics; DNA; Polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001542969,0.0002515952,0.0002362903,0.0002565836,0.000236875,0.0003457263,0.0002683513,0.0003282737,0.004932171],"category_scores_gemma":[0.0001614368,0.0001919004,0.000340824,0.0002262865,0.0002310383,0.0002067299,0.0001902783,0.0007671724,0.0009276471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003797355,"about_ca_system_score_gemma":0.0002031723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006193574,"about_ca_topic_score_gemma":0.001361373,"domain_scores_codex":[0.9998055,0.00002383599,0.000022155,0.00004325478,0.00005336146,0.00005189841],"domain_scores_gemma":[0.9998913,0.00001594572,0.00002747045,0.00002893801,0.00001110334,0.00002526708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003362306,0.00008128095,0.0004813483,0.00003449729,0.00001458255,0.00007415835,0.00001269319,0.000141666,0.9953588,0.0003188247,0.0003017291,0.002844056],"study_design_scores_gemma":[0.00004486546,0.0002545651,0.006180655,0.00000342287,0.00001468785,0.0003895628,0.00002691179,0.0008501639,0.9849589,0.00007667604,0.007195729,0.000003921522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884605,0.001943196,0.003448973,0.0004074041,0.0001311589,0.0000556505,0.001940221,0.0002924488,0.003320278],"genre_scores_gemma":[0.9928439,0.0003647711,0.001548096,0.00008084196,0.00000931759,0.00002662298,0.001380219,0.00002319954,0.0037229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004932171,"threshold_uncertainty_score":0.01649976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02156514824758506,"score_gpt":0.2987371539263188,"score_spread":0.2771720056787338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}