{"id":"W4318669778","doi":"10.1210/endocr/bqad023","title":"Beyond Expression: Role of Phosphorylated Residues of EZH2 in Lineage Plasticity in Prostate Cancer","year":2023,"lang":"en","type":"review","venue":"Endocrinology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"EZH2; PRC2; Prostate cancer; Epigenetics; Biology; Cancer research; Carcinogenesis; Phosphorylation; Cancer; DNA methylation; Histone; Cell biology; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000274859,0.0005315976,0.0007542062,0.001275204,0.0001625178,0.0006420726,0.00051543,0.0006959766,0.001889863],"category_scores_gemma":[0.0003138602,0.0001570219,0.0002409369,0.001283713,0.0003575259,0.0008502469,0.0004827931,0.001039961,0.001314029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005529723,"about_ca_system_score_gemma":0.0006196237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007606202,"about_ca_topic_score_gemma":0.00132464,"domain_scores_codex":[0.9999216,0.00001266801,0.00001075064,0.0000154327,0.00002932452,0.00001032051],"domain_scores_gemma":[0.9999053,0.00003657045,0.0000127057,0.000003114563,0.00002818012,0.0000140498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009527784,0.00003416581,0.0002627962,0.009486545,0.00006718263,0.0003481375,0.00006091894,0.0003607736,0.004699014,0.004399874,0.02969553,0.9504898],"study_design_scores_gemma":[0.00001109007,0.00006703366,0.001229152,0.001114588,0.00006779655,0.0018422,0.00003917631,0.00008409943,0.001057492,0.001700375,0.9927724,0.00001463834],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000169902,0.998238,0.0001383665,0.0002590514,0.0001878654,0.00000215929,0.00001588641,0.000006666953,0.0009820878],"genre_scores_gemma":[0.000998966,0.9976439,0.0001270729,0.0001927198,0.0001950631,0.000003825971,0.00002812822,0.000001585734,0.000808763],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001889863,"threshold_uncertainty_score":0.006322205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02565374395517208,"score_gpt":0.3345154000497394,"score_spread":0.3088616560945673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}