{"id":"W4318677453","doi":"10.1016/s2468-1253(22)00434-4","title":"Increased versus conventional adalimumab dose interval for patients with Crohn's disease in stable remission (LADI): a pragmatic, open-label, non-inferiority, randomised controlled trial","year":2023,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Norgine; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cilag; ZonMw; European Crohn's and Colitis Organisation; Radboud Universiteit; Celltrion; Teva Pharmaceutical Industries; United European Gastroenterology; Pfizer","keywords":"Medicine; Adalimumab; Open label; Randomized controlled trial; Confidence interval; Crohn's disease; Internal medicine; Complete remission; Disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002329897,0.0018867,0.004694476,0.0004999145,0.000550651,0.001699555,0.001111887,0.002986244,0.01127683],"category_scores_gemma":[0.003057077,0.0007319465,0.003189064,0.0004877922,0.001416025,0.001581489,0.0008447221,0.003945714,0.001404873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001050637,"about_ca_system_score_gemma":0.0007124654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000958158,"about_ca_topic_score_gemma":0.001510808,"domain_scores_codex":[0.9986454,0.0007770128,0.00009647314,0.0002102835,0.00009182787,0.0001791187],"domain_scores_gemma":[0.9986376,0.0006481037,0.0002534025,0.00009013579,0.00007308835,0.0002975362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9836081,0.0009343757,0.0002055712,0.001849282,0.001527292,0.00003504715,0.00004620469,0.0001262779,0.0006915875,0.0002080002,0.0006032513,0.0101651],"study_design_scores_gemma":[0.986371,0.01136003,0.0006407576,0.00009984861,0.0007014958,0.0000203152,0.00001954893,0.0001295034,0.00005694425,0.0001997274,0.0003895532,0.00001121392],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9285107,0.04595839,0.002014052,0.004181853,0.004432605,0.004895445,0.002139033,0.0003620627,0.007505871],"genre_scores_gemma":[0.9786345,0.005704261,0.00268657,0.003315655,0.001261681,0.004317143,0.000903995,0.00003268852,0.003143593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01127683,"threshold_uncertainty_score":0.03772479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01692880489892664,"score_gpt":0.2831936157195907,"score_spread":0.2662648108206641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}